ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 µm−0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1–8)-like material, which persisted for at least 90 min after treatment with 10 µm−0.1 mm of the compound. Co-administration of d-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP; 1 µm) to block spinal µ-opioid receptors did not modify this effect, whereas naltrindole (10 µm) totally prevented it and nor-binaltorphimine (10 µm) reduced the post-effect. These data suggest that 1DMe triggers the release of endogenous opioids that stimulate mainly δ-opioid receptors, and secondarily κ-opioid receptors, thereby exerting a negative influence on dynorphin A (1–8)-like material outflow. Because dynorphin has pronociceptive properties, such a decrease in spinal dynorphin A (1–8)-like material release might underlie the long-lasting antinociceptive effects of intrathecally administered neuropeptide FF and analogues.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1471-4159.2002.00914.x
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