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Eine Apparatur zur Messung motorischer Funktionsstörungen bei Ratten (1976)

Ballhause, H. ; Kähling, J.

Springer

Psychopharmacology 50 (1976), S. 281-283

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ISSN: 1432-2072

Keywords: Motor incoordination ; Runway test ; Diazepam ; Phenobarbital ; Chlorpromazine ; Rat

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract A runway apparatus for rats has been developed for measuring motor incoordination and running time. Animals were trained to run along an elevated narrow pathway. Frequency and severity of slipping off and running time were automatically counted. Rats were given diazepam, phenobarbital or chlorpromazine orally and tested 1 h later. Diazepam, 8–64 mg/kg p.o., caused slipping off in a dose-dependent manner. Phenobarbital had a similar effect with 64 mg/kg p.o. Chloropromazine, 32 and 64 mg/kg p.o., caused other signs of motor deficit.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00426845

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