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  • 1
    Electronic Resource
    Electronic Resource
    Effectiveness of combined anticoagulant therapy for extending portal vein thrombosis in Crohn's disease (1996)
    Springer
    Diseases of the colon & rectum 39 (1996), S. 823-825 
    Details
    ISSN: 1530-0358
    Keywords: Portal vein thrombosis ; Crohn's disease ; Anticoagulant therapy ; Color Doppler ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Portal vein thrombosis is a rare complication of Crohn's disease, and its precise cause and appropriate treatment are not known. We describe a patient with extending portal vein thrombosis in Crohn's disease who was successfully treated with combined anticoagulant therapy. METHOD: Urokinase and tissue plasminogen activator were administered from a catheter inserted into the superior mesenteric artery, and heparin and a serine protease inhibitor also were given intravenously. RESULTS: On admission, thromboembolic occlusion was observed throughout the entire portal venous system in association with massive ascites and remarkable intestinal edema. After administration of combined anticoagulant therapy, thrombus rapidly decreased in size, and color Doppler ultrasonography showed a gradual increase in portal venous flow. The patient had no recurrence of symptoms while receiving warfarin after resolution of thrombus. CONCLUSION: This case report suggests that combined anticoagulant therapy is effective for patients with severe portal vein thrombosis in Crohn's disease and that color Doppler ultrasonography is useful for evaluation of portal venous flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02054451
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  • 2
    Electronic Resource
    Electronic Resource
    Primary gastric Burkitt's lymphoma presenting with c-myc gene rearrangement (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 710-715 
    Details
    ISSN: 1435-5922
    Keywords: Key words: EB virus ; Southern blot ; immunoglobulin gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A 54-year-old man with primary gastric Burkitt's lymphoma is described. He was evaluated for appetite loss and intermittent midepigastric pain. Upper gastroduodenal endoscopy detected an ulcer in the lesser curvature of the body, and biopsy specimens revealed infiltration of medium-sized lymphoblasts with "starry sky" macrophages. The infiltrated cells were positive for a B-cell marker. Abdominal computed tomography scan demonstrated marked enlargement of the gastric wall, but no enlargement of lymph nodes. These findings led us to diagnose primary gastric Burkitt's lymphoma. The patient responded dramatically to CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy, but 6 months after his initial admission, the disease recurred in the stomach and bone marrow. Lymphoblastic cells were positive for B-cell markers (CD 10, 19, 20, and human leukocyte antigen [HLA]-DR) and showed an abnormal karyotype, 47, XY, t(8;14)(q24;q32), +12. In these cells, the Epstein-Barr virus genome was detected by polymerase chain reaction. Southern blot analysis revealed rearrangement of Ig heavy and light chain genes. In addition, c-myc gene rearrangement was detected. Eight months after the beginning of chemotherapy, the patient died of central nervous system involvement. To our knowledge, this is the first description of a genetic analysis of primary gastric Burkitt's lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050159
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of short-term administration of the CCK receptor antagonist, KSG-504, on regeneration of pancreatic acinar cells in acute pancreatitis in rats (1995)
    Springer
    Journal of gastroenterology 30 (1995), S. 493-499 
    Details
    ISSN: 1435-5922
    Keywords: CCK receptor antagonist ; pancreas ; pancreatitis ; regeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholecystokinin (CCK) receptor antagonists have been reported on have an inhibitory effect on acute experimental pancreatitis, but their long-term administration is also reported to block pancreatic regeneration. We examined whether the short-term administration of KSG-504 )KSG), a synthetic CCK-A receptor antagonist, inhibited the regeneration of pancreatic acinar cells after ethionine-induced acute pancreatitis in rats. KSG (50 mg/kg), given 12 times by subcutaneous injection at 6-h intervals, prevented the reduction of protein, amylase, and trypsinogen levels, and the DNA content of the pancreas and facilitated the recovery of these values. Ornithine decarboxylase activity in pancreatic tissue and a 5-bromo-2′-deoxyuridine labeling study indicated that DNA synthesis was accelerated in rats treated with KSG. These findings suggest that the short-term administration of KSG inhibits the development of ethionine-induced acute pancreatitis and facilitates the regeneration of acinar cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347566
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  • 4
    Electronic Resource
    Electronic Resource
    Aggressive jejunal γδT-cell lymphoma derived from intraepithelial lymphocytes: An autopsy case report (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 280-284 
    Details
    ISSN: 1435-5922
    Keywords: Key words: ascites ; jejunal lymphoma ; intraepithelial lymphocytes ; γδT-cell receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A 69-year-old man with massive ascites was referred to our hospital. Paracentesis revealed exudative ascites with many abnormal lymphocytes, which expressed T-natural killer (T-NK) cell surface markers and γδT-cell receptor (TCR). Although the ascites resolved for a short time with chemotherapy, gastrointestinal bleeding occurred and acute retention of ascites was observed. The patient died of panperitonitis. At autopsy, part of the jejunum revealed ulceration and marked mucosal thickening, and was perforated at the site of the severe ulceration. Histological examination showed massive infiltration of abnormal lymphocytes that were positive for CD45RO. Therefore, the cells responsible for the jejunal lymphoma and ascites were thought to be derived from γδIEL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050084
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  • 5
    Electronic Resource
    Electronic Resource
    Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats (2000)
    Springer
    Journal of gastroenterology 35 (2000), S. 341-346 
    Details
    ISSN: 1435-5922
    Keywords: Key words: short-chain fatty acid ; butyrate ; Clostridium butyricum M588 ; dextran sodium sulfate-induced colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Butyrate enemas have been reported to be effective in ulcerative colitis. However, long-term use is difficult because of the troublesome procedure and the unpleasant smell. We therefore investigated the effects of the oral administration of Clostridium butyricum M588 (CBM588), an enterobacterium producing butyrate, in dextran sodium sulfate (DSS)-induced colitis in rats. First, we confirmed the effects of pre-treatment with a butyrate enema on DSS colitis. We then studied the efficacy of oral administration of CBM588 which was started 1 week prior to the induction of DSS colitis. In the CBM588 group, the ulcer index and myeloperoxidase (MPO) activity in the distal colon were significantly lower than in the control group. Proliferating cell nuclear antigen (PCNA) immuno-positive cells were increased around the ulcer in the CBM588 group. In regard to the contents of the cecum and colon, the proportions of Lactobacillus and Eubacterium were increased in the cecum in the CBM588 group. Further, there were significant increases of n-butyrate, propionate, and acetate concentrations in the cecum in the CBM588 group. These results indicated that the oral administration of CBM588 alleviated DSS-induced colitis, and may be useful instead of butyrate enema.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050358
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  • 6
    Electronic Resource
    Electronic Resource
    Efficacy of oral adsorbent for treatment of peristomal fistula associated with Crohn's disease (2000)
    Springer
    Journal of gastroenterology 35 (2000), S. 296-298 
    Details
    ISSN: 1435-5922
    Keywords: Key words: fistula, Crohn's disease, oral adsorbent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Perianal fistulae are frequently seen complications in Crohn's disease. Although surgical procedures such as Seton's method have been devised, many patients still suffer from fistulae that are resistant to conventional therapy. We administreved oral adsorbent to a patient with disease Crohn's who had a complicated peristomal fistula that did not improve with conventional therapy. Six grams of oral adsorbent (AST-120) were added daily to a regimen of elemental diet therapy and prednisolone. The fistula gradually decreased in size after the administration of the oral adsorbent, and had healed completely after 40 days' treatment. There were no side effects from the oral adsorbent. This case report suggests that oral adsorbent is an effective treatment for peristomal fistula associated with Crohn's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050349
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  • 7
    Electronic Resource
    Electronic Resource
    Enhancement of brush border membrane peptidase activity in rat jejunum induced by starvation (2000)
    Springer
    Pflügers Archiv 440 (2000), S. 75-83 
    Details
    ISSN: 1432-2013
    Keywords: Aminopeptidase N Dipeptidyl peptidase IV Gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Conflicting results have been obtained in previous studies concerning the adaptation of intestinal brush border membrane enzymes to starvation. This study was designed to clarify the changes in these enzymes under starvation conditions, using a molecular biological approach. Sprague-Dawley rats were starved or given total parenteral nutrition (TPN) for 5 days. Rats allowed free access to food were used as controls. Changes in the activity and expression of jejunal brush border membrane enzymes were compared between three groups. In the starved group, aminopeptidase N and dipeptidyl peptidase IV activity was significantly elevated to 177% and 166%, respectively, of control values. In contrast, sucrase and maltase activity was significantly decreased. The activity of these peptidases also tended to be increased at the renal brush border membrane. Up-regulation of peptidase activity was not evident in the TPN group. Western and Northern blot analysis revealed that the changes in aminopeptidase N activity were attributable to increases in the protein and mRNA level. The activity and expression of brush border membrane peptidases in rat jejunum is up-regulated during starvation, and these changes are considered to be an effect of whole-body malnourishment, rather than an absence of luminal nutrition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240000275
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular Characterization of Complement Components (C3, C4, and Factor B) in Human Saliva (1997)
    Springer
    Journal of clinical immunology 17 (1997), S. 404-407 
    Details
    ISSN: 1573-2592
    Keywords: Salivary gland ; external secretion ; hemolytic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A molecular analysis of complement components (C3, C4, and factor B) in human saliva was performed by SDS-PAGE and immunoblotting. Complement C3 was detected as a molecule composed of a 115-kDa α-chain linked to a 70-kDa β chain by disulfide bonds, and C3 levels ranged from 0.52 to 15.0 /μg/ml (n = 15). C4 was detected as a triple-chain molecule (98-kDa α chain, 73-kDa β chain, and 33-kDa γ chain) linked by disulfide bonds, and C4 levels ranged from 0.086 to 4.8 μg/ml. Factor B was detected as a 100-kDa single chain, and factor B levels ranged from 0.042 to 0.62/μg/ml. The sizes and subunit structures of the complement components in human saliva were compatible with those reported in human serum. The results of a hemolytic assay indicated that the complement molecules in human saliva were functionally active. These complement components may participate in the local immune and inflammatory responses in the oral cavity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027320425291
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  • 9
    Electronic Resource
    Electronic Resource
    Case Report: Malignant Gastrointestinal Stromal Tumor of the Small Intestine Rare Complication of Acute Disseminated Intravascular Coagulation Without Hematogenous Metastasis (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 2271-2277 
    Details
    ISSN: 1573-2568
    Keywords: GASTROINTESTINAL STROMAL TUMOR ; LEIOMYOSARCOMA ; SMALL INTESTINE ; ACUTE DISSEMINATED INTRAVASCULAR COAGULATION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026674824211
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of intrinsic CCK and CCK antagonist on pancreatic growth and pancreatic enzyme secretion in pancreaticobiliary diversion rats (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 653-659 
    Details
    ISSN: 1573-2568
    Keywords: CCK ; CCK antagonist ; pancreatic growth ; pancreatic enzyme secretion ; pancreaticobiliary diversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When pancreaticobiliary diversion (PBD) surgery was performed in rats, plasma CCK level increased, the pancreas grew mainly by proliferation, and pancreatic trypsinogen showed a remarkable increase, although amylase and lipase synthesis were somewhat decreased. The sensitivity of amylase release against CCK-8 in the pancreatic acini decreased when plasma CCK level was high. These changes in pancreatic growth and pancreatic enzyme secretion caused by PBD were completely inhibited by the CCK-receptor antagonist loxiglumide. From these results, intrinsic CCK was considered to play an important role in both pancreatic enzyme synthesis and proliferation
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316796
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