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  • 1
    Electronic Resource
    Electronic Resource
    Parotid gland metastases of two uncommon neoplasms with low metastatic potential (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 26 (1997), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oligodendrogliomas are uncommon intracranial glial tumours in which extracranial spread is only rarely reported. Similarly, both intracranial and ocular medulloepkheliomas are also rare, with metastatic spread from the ocular neoplasm being less common than its intracranial counterpart. We report cases of an intracranial oligodendroglioma and an ocular medulloepithelioma both of which metastasised to the parotid gland. To our knowledge these are only the second oligodendroglioma and the third ocular medulloepithelioma to be reported as metastasising to this site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1997.tb00237.x
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacological comparison of the sigma recognition site labelled by [3H]haloperidol in human and rat cerebellum (1992)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 345 (1992), S. 197-202 
    Details
    ISSN: 1432-1912
    Keywords: Sigma recognition sites ; Human cerebellum ; Rat cerebellum ; [3H]haloperidol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The radioligand binding characteristics of [3H]haloperidol (in the presence of spiperone, 25 nmolL−1) were investigated in rat and human cerebellar membranes. In both rat and human cerebellar membrane preparations saturation studies with [3H]haloperidol (non-specific binding defined by pentazocine, 10 μmolL−1) demonstrated high affinity saturable specific binding to a homogenous population of binding sites (rat, Bmax 6693 ± 1242 fmol mg−1 protein, pKD 8.33 ± 0.08; human, Bmax 2550 ± 437 fmol mg−1 protein, pKD 8.59 ± 0.11; mean ± SEM, n = 3–6). Competition studies employing a wide range of structurally diverse competing compounds displayed that the [3H]haloperidol binding site was pharmacologically similar in both preparations and comparable to sigma recognition sites previously identified in various tissues originating from different species. In addition, with reference to the potential subtypes of sigma recognition sites, the labelling of these sites by low nanomolar concentrations of [3H]haloperidol provides evidence that they belong to the sigma-1 recognition site subtype. The present findings suggest that the pharmacology of the rat and human cerebellar sigma recognition site are directly comparable and provides further supporting evidence towards the use of [3H]haloperidol radioligand binding studies in the rat to detect sigma receptor ligands with potential therapeutic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165736
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  • 3
    Electronic Resource
    Electronic Resource
    Long Baseline Interferometry of the Seyfert Galaxy 3C84 (1973)
    [s.l.] : Nature Publishing Group
    Nature 244 (1973), S. 18-19 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A long baseline interferometer was formed by the 45-m telescope at the Algonquin Radio Observatory and the 25-m telescope at Chilbolton. At the operating frequency of 10,680 MHz, the baseline of 5,265 km represents a separation between telescopes of 187106 wavelengths. Each station received ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/244018a0
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  • 4
    Electronic Resource
    Electronic Resource
    Glial fibrillary acidic protein (GFAP)-like immunoreactivity in normal and transected rat olfactory nerve (1987)
    Springer
    Experimental brain research 65 (1987), S. 681-685 
    Details
    ISSN: 1432-1106
    Keywords: Olfactory nerve ; GFAP ; Monoclonal antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Normal and transected rat olfactory nerves were stained immunohistochemically using a monoclonal antibody previously shown to selectively detect GFAP-like immunoreactivity in central astrocytes but not in peripheral Schwann cells. Low levels of “central” type GFAP were found in the olfactory nerves, presumably in ensheathing cells. The levels of GFAP increased dramatically after nerve transection. A population of strongly GFAP-positive cells was detected at the junction between the olfactory epithelium and initial part of the nerves, of possible relevance to the regenerative abilities of this pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235993
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  • 5
    Electronic Resource
    Electronic Resource
    The distribution of Thy-1 antigen in the P.N.S. of the adult rat (1983)
    Springer
    Journal of neurocytology 12 (1983), S. 1017-1039 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of the cell surface glycoprotein Thy-1 in the P.N.S. of adult rats was examined using immunohistochemical and experimental techniques. In the hypoglossal nerve the pattern of Thy-1 labelling suggested the antigen was on the plasma membrane of all axons, not only in their major myelinated course but also on their fine terminal branches and at the motor end plate itself. Similarly in other peripheral nerves examined [phrenic and vagus nerves, dorsal and ventral roots, and both the preganglionic and postganglionic trunks of the superior cervical ganglion (SCG) and the submandibular ganglion] Thy-1 was always associated with axons, but the resolution obtained with immunohistochemical techniques was not in itself sufficient to exclude the possibility that the antigen was on the surface of the ensheathing Schwann cell where it apposed the axons. However, in the hypoglossal nerve the antigen was found to accumulate proximal to a ligation of the nerve, suggesting it was made by the neurons and transported down the nerve by axoplasmic flow. This impression was supported by examining neuronal cell bodies in the SCG, dorsal root ganglia and submandibular ganglion, all of which contain readily detectable cytoplasmic Thy-1. In the SCG this cytoplasmic antigen was shown to include the pool of newly synthesized Thy-1. It was increased by treatment of the ganglion with colchicine, and decreased by cycloheximide. Conversely, treatment of hypoglossal nerve trunk with colchicine did not lead to the appearance of the antigen around the non-neuronal perikarya. It is therefore concluded that in those parts of the adult rat P.N.S. examined, Thy-1 is made by neurons and occurs generally on the plasma membrane of axons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01153348
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  • 6
    Electronic Resource
    Electronic Resource
    Early stages of Purkinje cell maturation demonstrated by Thy-1 immunohistochemistry on postnatal rat cerebellum (1985)
    Springer
    Journal of neurocytology 14 (1985), S. 427-452 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cell surface glycoprotein, Thy-1, is present on Purkinje cells at birth, so allowing Thy-1 immunohistochemistry to demonstrate the final stage of migration and the transition to dendritic growth of these cells. In the most caudal lobule of the cerebellar cortex of the newborn rat, migrating Purkinje cells are found. These have a prominent process (up to 50 μm long) from which fine filopodia project, presumably sensing the environment in front of the cell. These cells are orientated tangentially, at right angles to the radial orientation they assume for dendritic growth. Strong Thy-1 labelling is found not only on their surface, but also on a cytoplasmic cap above the presumed leading pole of the nucleus. More rostrally in the cerebellar cortex, Purkinje cells arrive up to 3 days before birth and are quiescent until the postnatal development of their dendritic tree. At birth and during early postnatal periods a rounded cell is found with little cytoplasm; Thy-1 staining labels its surface and the fine processes which emanate from it. Such cells coexist with other Thy-1-positive Purkinje cells with more developed surface orientated processes. Even as early as the day of birth these fine processes cross the molecular layer and contact the lower level of the external granule layer. Orientated dendritic growth appears to occur by a selective thickening of these processes and a massive apical protrusion of intensely Thy-1-positive cytoplasm. The whole of the Purkinje cell surface membrane exhibits high levels of Thy-1 throughout dendritic growth and synaptogenesis, and cytoplasmic antigen is prominent during the period of greatest growth. Thy-1 is also found on the neurons of the deep cerebellar nuclei, and is seen transiently on Golgi interneurons. High levels of the antigen are present on blood vessels and choroid plexus at birth but are lost from these structures over the first 2 postnatal weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01217754
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  • 7
    Electronic Resource
    Electronic Resource
    Late emergence of Thy-1 on climbing fibres demonstrates a gradient of maturation from the fissures to the folial convexities in developing rat cerebellum (1985)
    Springer
    Journal of neurocytology 14 (1985), S. 453-467 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the third week of postnatal life, Thy-1 staining of Purkinje cells starts to decrease, first in the depths of the fissures and then progressively, over the next 10 weeks, up the walls of the fissures to the convexities of the folia. This is accompanied by a far more striking appearance of high levels of Thy-1 on a network of fibres whose distribution strongly suggests they are climbing fibres. They acquire the antigen in the same topographical gradient of maturation, and at the same time, as Purkinje cells lose it. That these are climbing fibres was confirmed by destroying the inferior olive with 3-acetylpyridine, which also eliminated the intense Thy-1 staining in the cerebellum. At a stage (18 days) when only some climbing fibres in the molecular layer are seen to be Thy-1-positive, only a proportion of inferior olivary neurons are Thy-1-posirive with intense antigen labelling over the Nissl substance. The possibility that Thy-1 also appears on mossy fibres, and at relatively low levels on parallel fibres, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01217755
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