ISSN:
1365-2230
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Forty-eight adult patients with chronic urticaria have been evaluated for scrum antibodies reactive with bovine milk, chicken ovalbumin or wheat gliadin using a solid-phase enzyme-linked immunosorbent assay (ELISA). Of the chronic urticaria sera, 60.4% contained detectable antibodies reactive with one or more of these dietary antigens, compared with 33.9% of sera from 232 healthy adults (P 〈 0.001). In particular, antibodies reactive with milk (52%; P 〈 0.001), ovalbumin (39.6%, P 〈 0.001) and gliadin (20.8%, P 〉 0.05) were detected at increased frequencies compared with controls (22.8%, 16.8% and 11.6%, respectively). These serum antibodies were predominantly of the IgG isotype, with an IgG subclass restriction mainly to IgG4 for anti-ovalbumin and anti-gliadin antibodies, and to IgG2 and IgG4 for anti-milk antibodies. The increased frequency of IgG antibodies was not significantly associated with either raised total serum IgE or atopic status.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-2230.1987.tb01940.x
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