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  • 1
    Electronic Resource
    Electronic Resource
    The Occurrence of γ-Aminobutyrylcholine in Mammalian Brain—Fact or Artefact? (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 40 (1983), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: γ-Aminobutyrylcholine (GABACh) has been reported to exist in mammalian brain tissue, but not, as yet, given a specific physiological role in the CNS. In order to investigate further its occurrence and function in the CNS, two new methods have been developed for its isolation and determination at the picomole level. Its isolation has been achieved by ammonium Reineckate precipitation or by cation-exchange followed by HPLC determination of the dansyl and O-phthaldialdehyde derivatives. Using these methods, no free endogenous GABACh (〈80 pmol/g) was found in rat, guinea pig, cat, pig, marmoset, or human brain tissue. No evidence was obtained, either in vitro or in vivo, for the incorporation of [14C]choline or [14C]γ-aminobutyric acid into GABACh. GABACh was hydrolysed at a low rate (maximum of 45 nmol/h/g of brain tissue) after incubation with rat, guinea pig, or cat brain minces and homogenates. These results fail to confirm the data of other investigators, and the possible reasons for this are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1983.tb12660.x
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  • 2
    Electronic Resource
    Electronic Resource
    Neurofibroma with aberrant tactile corpuscles (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 161-165 
    Details
    ISSN: 1432-0533
    Keywords: Neurofibroma ; Pacinian neurofibroma ; Pacinian Corpuscles ; Meissner's Corpuscles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes an unusual plexiform neurofibroma from a child with von Recklinghausen's disease that was characterized by the presence of numerous aberrant tactile corpuscles in both the original and recurrent tumor. The individual corpuscles appeared to be composed of combination of a Pacinian exterior and a meissnerian interior. This neoplasm is discussed in relation to previous reports of Pacinian neurofibromas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00710325
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  • 3
    Electronic Resource
    Electronic Resource
    Retention behavior of morphine and its metabolites on a porous graphitic carbon column (1998)
    Springer
    Chromatographia 47 (1998), S. 667-672 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Porous graphitic carbon ; Optimization ; Morphine and metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The chromatographic behaviour of a series of morphine-based opiates has been investigated using a porous graphitic carbon packing material at acid and alkaline pH. The effects of mobile phase pH, mobile phase organic percentage, column temperature and ionpairing agents were studied. All six opiates were separated within a close retention window despite large differences in measured lipophilicities of the individual opiates. The retention order was not related to the log P values of the opiates and strong retention of the fully ionised compounds was observed, particularly those with acidic functional groups. The effect of pH on the retention of the compounds indicated that the degree of ionisation of the individual compounds was important in the separation mechanism, suggesting that hydrophobic interactions were present in addition to the polar retentive effects observed above. The strong retention of the ionised glucuronide and sulphate conjugates of morphine is a particularly useful feature of the porous graphitic carbon packing material which has general applicability to the analysis of polar or ionised drug metabolites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467451
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of a range of alkyl-bonded silica HPLC stationary phases: XPS and ToF-SIMS studies (1994)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 21 (1994), S. 263-273 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A series of alkyl-bonded silica HPLC stationary phases with a mean particle diameter of 5 μm has been prepared using a variety of dimethylalkylsilyl chlorides (i.e. monofunctional bonding agents) with alkyl chain lengths varying from C1 to C18, including phenyl and cyanopropyl groups. The stationary phases have been characterized using XPS and time-of-flight (ToF)-SIMS. Elemental analyses by XPS have identified trace quantities of iron, sodium and chlorine at the silica/dimethylalkylsilyl chain interface, and aluminium was detected by ToF-SIMS. A comparison of percentage carbon obtained by XPS with bulk carbon-loading analyses suggests that the alkyl chains are bonded to the surface of the porous silica particles. Molecular ions characteristic of the dimethylalkylsilyl groups were identified in the ToF-SIMS data together with ions attributable to these alkylsilyl groups attached to fragments of silica, the latter indicating covalent bonding to the silica surface. In addition, a series of low-mass signals corresponding to alkyl chain fragments and silyl/silica-based ions was observed. The value of high-resolution ToF-SIMS data for ion assignments is well demonstrated. The relative ion intensities of several of these low-mass ions were studied as a function of changing alkyl chain length. In general, as the alkyl chain length increased, the abundance of the silicon-containing fragments decreased, whilst the abundance of the alkyl-based fragments increased, within the ToF-SIMS spectra.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740210502
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