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  • 1
    Electronic Resource
    Electronic Resource
    Silikonöl in der Netzhautchirurgie (2000)
    Springer
    Der Ophthalmologe 97 (2000), S. 514-525 
    Details
    ISSN: 1433-0423
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Seit der Einführung in die vitreoretinale Chirurgie 1962 hat die intraokulare Tamponade mit Silikonöl einen festen Platz in der Augenheilkunde eingenommen. Silikonöl wird dabei nicht nur zur Tamponade retinaler Defekte eingesetzt, sondern dient ferner auch der Stabilisierung des intraokulären Milieus. Die Dekompartimentierung beschränkt zum einen postoperative Blutungen, senkt aber auch die Menge der intravitreal zirkulierenden Mitogene. Gleichzeitig wird eine Wiederablösung der Netzhaut durch Reproliferationen in ihrer Ausdehnung begrenzt. Aufgrund dieser Vorteile wird Silikonöl in der Behandlung der fortgeschrittenen proliferativen Vitreoretinopathie (PVR), z.B. nach schweren Augenverletzungen, auch zur Langzeittamponade eingesetzt. Daneben bietet die Silikonöltamponade einen effektiven therapeutischen Ansatz in der Behandlung der proliferativen diabetischen Retinopathie, bei schweren Augenverletzungen, virusbedingter nekrotisierender Retinitiden, bei der Behandlung von Makulaforamen und persistierenden Hypotonien. Eine anfänglich vermutete Unverträglichkeit durch Verunreinigungen ist seit der Einführung von hochgereinigtem und fraktioniertem Silikonöl überwunden. Gleichzeitig ist die Rate schwerer Komplikationen wie Sekundärglaukom oder Keratopathie durch die Weiterentwicklung der chirurgischen Techniken deutlich gesunken. Stabile Langzeitverläufe mit Silikonöl Dauertamponaden von weit über 10 Jahren begründen eine gute Verträglichkeit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003470070085
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  • 2
    Electronic Resource
    Electronic Resource
    Autologous platelet treatment for optic disc pit associated with persistent macular detachment (1998)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 236 (1998), S. 151-153 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  • Purpose: To determine the effectiveness of autologous platelets in repair of optic disc pit associated with persistent macular detachment. • Patient: We report on a 44-year-old woman with optic disc pit associated with persistent macular detachment. The patient underwent an uneventful pars plana vitrectomy with autologous platelets injected over the optic disc pit. Good anatomical and functional results were obtained. • Conclusion: This surgical approach may be a valuable adjunct to the surgical management of optic disc pit associated with persistent macular detachment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004170050056
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of spatial thresholds and intensity thresholds in glaucoma (1993)
    Springer
    International ophthalmology 17 (1993), S. 171-178 
    Details
    ISSN: 1573-2630
    Keywords: conventional perimetry ; functional loos ; glaucoma ; ring perimetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spatial resolution perimetry and conventional perimetry measure different qualities of the functional performance of the eye. Theoretically, spatial resolution is directly related to the density of intact sensory units, but the relation of intensity to the density of intact sensory units is unknown. Previous studies indicated an almost linear relationship of global indices of spatial thresholds and intensity thresholds. The purpose of our study is to look at any difference in the behaviour of local threshold values and their precise relation. We examined 41 eyes of 23 patients with open angle glaucoma. Perimetry was carried out using the Humphrey Field Analyzer, and program 30-S or program 30-2 and the ring perimeter and standard program. Because test point patterns of the two examinations were different, the best matching points were calculated. If the distance between next points in both examinations was more than 5 degrees, the location was excluded. The Humphrey program 30-2 provided 47 matching points, the Humphrey program 30-S furnished 49 matching points for 50 locations. For the range of 20.36 dB in conventional perimetry, linearity could be verified in relation to the local thresholds in ring perimetry. The spatial threshold units used in the ring perimeter are the logarithm of spatial extend. Vice versa, spatial resolution is a power function of spatial thresholds. Based on the linear relationship of both thresholds, spatial resolution is a power function of intensity thresholds. In other words, if the intensity threshold is reduced from 36 to 30 dB, the spatial resolution is nearly half. If intensity threshold is reduced by a further 6 dB, spatial resolution is diminished to one quarter, and so on. If we accept that two-dimensional spatial resolution is directly related to the density of functional units, most of these units are lost when only small changes in dB values of conventional perimetry occur. For revaluation of visual fields in early glaucoma, our results are important for the otherwise rather meaningless decibel numbers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01007736
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  • 4
    Electronic Resource
    Electronic Resource
    Limits of two-dimensional planimetry in the follow-up of glaucomatous optic discs (1996)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 234 (1996), S. 69-69 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186523
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  • 5
    Electronic Resource
    Electronic Resource
    Communication between the subretinal space and the vitreous cavity in the morning glory syndrome (1996)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 234 (1996), S. 409-409 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190719
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  • 6
    Electronic Resource
    Electronic Resource
    Limits of two-dimensional planimetry in the follow-up of glaucomatous optic discs (1995)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 233 (1995), S. 284-290 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract •Background: To test the intra-observer, intra-photographic variability of two-dimensional measurements of the optic nerve head we used computer-assisted planimetry. Depending on the variability, we calculated the confidence intervals of the optic disc parameters which could be indicative of glaucomatous damage on follow-up. •Methods: Slides of the optic disc were taken from 10 eyes of 10 patients (n = 6 open angle glaucoma, n = 4 ocular hypertension) using a Zeiss fundus camera. All eyes were evaluated 10 times within a random sequence on 10 different days. We obtained the absolute values of the disc radii and the cup radii in steps of 1, 10, and 45 deg in predefined quadrants and the mean radii. •Results: The confidence interval of the cup radius on follow-up, depending on sector size, ranged between 62 and 38 % for small cups (radius 0.2 mm) and between 12 and 7% for large cups (radius 0.8 mm). The confidence intervals of the cup/disc ratio distinguishable from the disc boundary, depending on sector size, ranged between 0.81 and 0.89 for small discs (radius 0.5 mm) and from 0.90 to 0.94 for large discs (radius 1.0 mm). The confidence intervals of the cup/disc ratio indicating an increase on the cup radius in follow-up, distinguishable from the boundary of the disc, ranged, depending on sector size, between 0.57 and 0.75 for small discs (radius 0.5 mm) and from 0.81 to 0.89 for large discs (radius 1.0 mm). 9 Conclusion: The smaller the disc, the more difficult is the detection of glaucomatous damage, and the larger the cup, the more difficult is the detection of progression of glaucomatous damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177650
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  • 7
    Electronic Resource
    Electronic Resource
    Ganciclovir for the treatment of anterior uveitis (2000)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 238 (2000), S. 905-909 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background: Ganciclovir, administered systemically or intraocularly, is effective in controlling cytomegalovirus (CMV) retinitis in immunocompromised patients. The efficacy of therapy with this antiviral substance was investigated in an immunocompetent patient with CMV uveitis causing secondary glaucoma. Methods: To identify the presence of an intraocular viral infection, anterior chamber taps to detect the intraocular synthesis of IgG antibodies and PCR testing were carried out. Clinically, the degree of intraocular inflammation and the intraocular pressure (IOP) values were monitored. During this time, the patient was treated systemically with ganciclovir administered orally and intravenously. Results: The intraocular synthesis of IgG antibodies specific for CMV was found in two samples of aqueous humor, but negative for other viruses. PCR testing was negative for HSV, VZV and CMV at each time. During this time, the patient was treated systemically with ganciclovir administered either intravenously or orally. As a response to therapy with ganciclovir, the elevated IOP values decreased to normal and the intraocular inflammation declined. After cessation of ganciclovir administration, the inflammation and secondary glaucoma recurred. Conclusion: In this case of anterior uveitis presumably caused by CMV inducing secondary glaucoma, treatment with ganciclovir led to a decrease of the inflammation and normalization of IOP. It appears that continuous administration may be required to control the infection in an immunocompetent patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004170000193
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  • 8
    Electronic Resource
    Electronic Resource
    Pars plana vitrectomy, endolaser coagulation of the retina and the ciliary body combined with silicone oil endotamponade in the treatment of uncontrolled neovascular glaucoma (1999)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 237 (1999), S. 969-975 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  · Purpose: Neovascular glaucoma develops on a background of ischemic ocular pathologies, such as diabetic eye diseases or central retinal vein occlusion. Development of neovascular membranes in the chamber angle leads to elevated intraocular pressure (IOP). Since cyclodestructive therapy or drainage surgery often fails, we have examined intense antiproliferative surgery as a treatment for advanced neovascular glaucoma. · Patients and methods: Thirty-two patients with uncontrolled neovascular glaucoma (mean IOP 45.5 mmHg) subsequent to central retinal vein occlusion or advanced diabetic retinopathy underwent antiproliferative surgery, which comprised pars plana vitrectomy, panretinal laser treatment and direct laser coagulation of the ciliary processes, followed by silicone oil tamponade. Patients were followed up for a minimum of 1 year and as long as 3 years. · Results: One week following surgery the IOP was normal, ranging from 8 to 21 mmHg, in 52% of eyes (15/29). After 3 months the IOP was normal in 50% (16/32); after 6 months, in 59% (16/27); and after 1 year, in 72% (18/25). Of the 10 eyes that lost all sight after the surgery, 7 eyes had a history of central retinal vein occlusion. Hypotony was observed in 6% of the eyes (2/32) 3 months after surgery; after 6 months hypotony was present in 15% (4/27), and after 1 year hypotony was present in 12% (3/25). · Conclusions: The theoretical premise of our surgical intervention (antiproliferative surgery) is that laser treatment interrupts the self- enhancing pathway of retinal ischemia, release of proliferative factors and increase in intraocular pressure. The silicone oil endotamponade prevents postoperative complications and supports the rapid regression of rubeosis iridis by separating the anterior from the posterior segment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004170050332
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