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  • 1
    Electronic Resource
    Electronic Resource
    Medullary-thyroid-carcinoma imaging in an animal model: Use of radiolabeled anticalcitonin F(ab′)2 and meta-iodobenzylguanidine (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 198-200 
    Details
    ISSN: 1619-7089
    Keywords: Medullary thyroid carcinoma ; Scintigraphy ; Radiolabeled anti-calcitonin ; mIBG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radiolabeled anti-calcitonin (CT) immunoglobulin fragments (131I-anti-CT F(ab′)2) and meta-iodobenzylguanidine (131I-mIBG) were injected into nude mice with a transplanted medullary thyroid carcinoma (MCT). 131I-Anti-CT F(ab′)2 proved to be unsuitable for MCT scintigraphic imaging. However, a high mIBG uptake was observed in MCTs, but not in control tumors (mesothelioma). The uptake of mIBG was not modified by the presence of reserpine or pentagastrine. These results are discussed, and it is suggested that mIBG could be an APUD-system marker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279068
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Postoperative assessment of cerebral blood flow in subarachnoid haemorrhage by means of99mTc-HMPAO tomography (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 53-58 
    Details
    ISSN: 1619-7089
    Keywords: Technetium-99m hexamethylpropylene amine oxime ; Single photon emission tomography ; Ischaemia ; Subarachnoid haemorrhage ; Vasospasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Regional hypoperfusion is a very frequent complication of subarachnoid haemorrhage (SAH), being related to vasospasm in the majority of cases. Twenty-six patients who were admitted for SAH underwent follow-up with technetium-99m hexamethylpropylene amine oxime single photon emission tomography (SPECT) 3 and 8 days after surgery. Fifteen patients of these had one more examination 15 days after surgery. The degree of hypoperfusion was quantified using an index of asymmetry which allow the comparison of two symmetrical regions of interest (ROIs) on the transaxial slice which presented the greatest perfusion defect. Comparison of CT data, transcranial Doppler data and clinical signs with the perfusion as quantified by99mTc-HMPAO SPECT indicates that a difference in counts of less than 10% between the two symmetrical ROIs is of no diagnostic value. Follow-up of the brain perfusion clearly shows that the most pronounced hypoperfusion was observed just after surgery, with progressive normalization at 8 and 15 days after surgery.99mTc-HMPAO SPECT performed 8 days after surgery allows prediction of the clinical outcome. For these reasons,99mTc-HMPAO SPECT, which is the only method for follow-up of cerebral perfusion in routine clinical practice, should be the first examination to be performed after surgery in patients with SAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02261246
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of MIBG and monoamines uptake mechanisms: Pharmacological animal and blood platelets studies (1988)
    Springer
    European journal of nuclear medicine 14 (1988), S. 341-344 
    Details
    ISSN: 1619-7089
    Keywords: MIBG ; Monoamine uptake ; Blood platelets ; Rat ; 6OH-DA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The uptake of MIBG, a scintigraphic agent widely used in the detection of APUD tumors, was studied with a pharmacological approach on an in vitro and an in vivo models. MIBG as well as norepinephrine (NE) was taken up by human blood platelets, a model for presynaptic nerve endings amine uptake, with a thermodependant mechanism. MIBG and NE uptake was inhibited by desimipramine and reserpine. However, MIBG but not NE uptake was inhibited by fluvoxamine, a serotonin (5HT) uptake inhibitor. This suggests that MIBG is a NE and also a 5HT uptake tracer which involves uptake one and vesicular storage mechanisms. In rats treated with 6-hydroxydopamine to induced a chemical sympathectomy, we observed an inhibition of uptake similar for MIBG and NE in the heart, the salivary glands and the spleen, but no effect was observed in the liver. Some clinical inferences to best investigate specific monoamine uptake are drawn from these results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254380
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  • 4
    Electronic Resource
    Electronic Resource
    Increment of brain temporal perfusion during auditory stimulation (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 981-983 
    Details
    ISSN: 1619-7089
    Keywords: Scintigraphy ; Auditory stimulation ; Technetium-99m-D,L hexamethylpropylene amine oxine (99mTc-HMPAO) ; Temporal cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A study on the dynamic exploration of the auditory pathway is presented, in which technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPET) was used in volunteers with normal hearing. Changes in 99mTc-HMPAO distribution were calculated using a region of interest/whole-brain count ratio. The results showed a temporal perfusion increment of 17% (right) and 19% (left) during tonal supraliminar stimulation, which was significantly different from the control ROI. Sensitivity tests for the method were requested before any clinical application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180420
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  • 5
    Electronic Resource
    Electronic Resource
    Reliability of low-frequency auditory stimulation studies associated with technetium-99m hexamethylpropylene amine oxime single-photon emission tomography (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 387-390 
    Details
    ISSN: 1619-7089
    Keywords: Auditory cortex ; Technetium-99m hexamethylpropylene amine oxime ; Auditory stimulation ; Reliability ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Development of auditory stimulation tests associated with single-photon emission tomography (SPET) shows evidence of variations in perfusion related to the stimuli. Three brain SPET examinations with technetium-99m hexamethylpropylene amine oxime were performed on eight right-handed adults with normal hearing, the first one without stimulation and the other two associated with a 500-Hz/30-dB stimulation of the right ear. Temporal regions of interest covering auditory areas, as well as parietal ones (internal control), were drawn on three successive coronal slices. A cortico-cerebellar index R was calculated, and the variation in activity was defined for each subject using the ratio R poststlmulation — R prestiunulation/R prestimulation. A significant increase in the temporal cortex count occurred in all subjects. This increase was bilateral, except for one subject in whom it was not significant on the right side. This result recurred during the second stimulation study. Overall the response of the left temporal cortex was stronger, although the asymmetry was not significant. The asymmetry repeated itself after each stimulation. The perfusion response is globally reliable in our study. We must ascertainhow sensitive this test is with regard to deaf adults and adults with normal hearing before extending its use to children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208996
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  • 6
    Electronic Resource
    Electronic Resource
    Meta-iodobenzylguanidine adrenal medulla localization: Autoradiographic and pharmacologic studies (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 278-281 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the mechanism of uptake of meta-iodobenzylguanidine (mIBG) by the adrenal glands, autoradiographic and pharmacologic studies were performed in mice and dogs receiving radioiodinated mIBG. In mice, on macroautoradiography of whole body sections 48 h after125I-mIBG, most of the radioactivity was focused in the adrenal glands. On microautoradiography, silver grains were exclusively located in the adrenal medulla. Tissue counting after phenoxybenzamine, cocaine, and desipramine treatment resulted in 45%, 35%, and 0% inhibition of mIBG uptake, respectively. Tissue counting and scintigraphic studies demonstrated a more than 50% mIBG release from the adrenal glands after reserpine. These data indicate the high affinity of mIBG for adrenal medulla and suggest that the mIBG and catecholamine uptake mechanisms are only partially the same.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00803250
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  • 7
    Electronic Resource
    Electronic Resource
    Cortical perfusion response to an electrical stimulation of the auditory nerve in profoundly deaf patients: study with technetium-99m hexamethylpropylene amine oxime single photon emission tomography (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 283-286 
    Details
    ISSN: 1619-7089
    Keywords: Profound deafness ; Temporal cortex ; Electrical stimulation ; Technetium-99m hexamethylpropylene amine oxime ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Brain activation procedures associated with single photon emission tomography (SPET) have recently been developed in healthy controls and diseased patients in order to help in their diagnosis and treatment. We investigated the effects of a promontory test (PT) on the cerebral distribution of technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) in 7 profoundly deaf patients, 6 PT + and one PT-. The count variation in the temporal lobe was calculated on 6 coronal slices using the ratio (Rstimulation— Rdeprivation)/Rdeprivation where R=counts in the temporal lobe/whole-brain count. A count increase in the temporal lobe was observed in all patients and was higher in all patients with PT + than in the patient with PT-. The problems of head positioning and resolution of the system were taken into account, and we considered that the maximal count increment was related to the auditory cortex response to the stimulus. Further clinical investigations with high-resolution systems have to be performed in order to validate this presurgery test in cochlear implant assessment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175143
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