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  • 1
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 32 (1987), S. 335-338 
    ISSN: 1432-1041
    Keywords: chlorthalidone ; magnesium depletion ; hypertension ; adverse effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Sixty patients were treated for 1 year for essential uncomplicated hypertension, 30 with beta-blockers alone (BB) and 30 with BB and chlorthalidone (CTD). BB did not affect serum K+ or Mg++. In the BB-group there was a statistically significant trend towards retention of Mg++ in a loading test, but the effect was clinically marginal. BB + CTD reduced serum K+ and Mg++ and caused significant Mg++ depletion, as shown by the Mg++ loading test. All the effects were highly significant and were clinically important. The metabolic perturbations due to CTD are potentially dangerous and make this drug unattractive as ‘first choice’ treatment for hypertension.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Sozial- und Präventivmedizin 16 (1971), S. 349-355 
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The project and execution of an epidemiological long-term study from 1968 to 1972 on the regular intake of analgesics in 1250 working women and the age group of 30 to 49 years in 80 companies in Northwestern Switzerland are described in detail. The purpose of the study is to estimate the risk of urorenal disease. A preliminary study in 1965 showed that working women in middle age are inclined to the regular intake of analgesics. The general procedure with a screening phase, evaluation phase, control phase and completion after 5 years with questionnaires, blood and urine tests is described. In the appendix the analytic methods used are mentioned.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Sozial- und Präventivmedizin 20 (1975), S. 240-241 
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The abuse of analgesics is common in the Swiss population. In a field study social und psychological investigations with 600 women ingesting analgesics and 600 women not taking analgesics are made. In a preliminary interpretation of 80 interviews the women ingesting analgesics differ only in a few points from the control group: 1. In the study group a greater number of women has children, however on the average a lower number than the control group. 2. The children of the women ingesting analgesics are more often taken care of outside their own home. 3. As an overwhelming event in life the loss of one or both parents was often mentioned. 4. Questions asked with regard to depressive symptoms were similar for both groups.
    Notes: Résumé L'abus d'analgésiques est très répandu dans notre population. Chez 600 consommatrices d'analgésiques et 600 personnes de contrôle des enquêtes anamnestiques sociales et psychiatriques-psychologiques ont été faites. Le bilan provisoire de 80 interviews de chaque groupe ne montre que dans peu de points des tendances dans lesquelles le groupe d'étude se différencie du groupe de contrôle. 1. Dans le groupe d'étude un plus grand nombre de femmes ont des enfants, toutefois en moyenne un nombre plus petit. 2. Les enfants du groupe d'étude sont gardés plus fréquemment hors de la maison. 3. La perte d'un ou des deux parents est indiquée plus fréquemment comme événement marquant. Le questionnaire concernant la depression ne se distingue guère dans les deux groupes.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Sozial- und Präventivmedizin 20 (1975), S. 242-243 
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary From 1968 to 1972 and in 1975 (provisional results) urine samples collected on three days per year were examined by photometer for N-acetyl-p-aminophenol ( = NAPAP, main metabolite of phenacetin) and for salicylates in the same population. It consists of 1200 women born from 1918 to 1937 whose majority works in 80 enterprises of Northwestern Switzerland. In 1968 half of the women showed regular intake of phenacetin containing analgesics ( = study group) in contrast to the other half that did not ( = control group). Excretion of salicylates was no criterion for grouping. Between 1968 and 1972 the total of women positive for NAPAP in urine decreased from 50 % to 35 %. The decrease concerns almost exclusively women positive for NAPAP on one or two days, whereas the number of women positive on all three days remained stable. At the same time the total number of women positive for salicylates decreased too. Possible reasons for the decreasing tendency of analgesics intake are mentioned. The much more frequent excretion of salicylates in the study group in contrast to the controls is probably due to the intake of combined analgesics. The provisional results of 1975 are in accordance to those observed previously.
    Notes: Résumée De 1968 à 1972 et en 1975 (résultats provisoires) des échantillons d'urine de trois jours par an ont été examinés par photométrie pour N-acetyl-p-aminophénol ( = NAPAP, métabolite principal de phénacetine) et pour salicylate chez une population constante. Il s'agit de 1200 femmes nées entre 1918 et 1937 dont la plupart travaillent dans 80 entreprises de la Suisse nordouest. En 1968 la moitié des femmes prenait régulièrement des analgésiques contenants de phénacetine ( = groupe d'étude) contrastante avec l'autre moitié qui n'en prenait pas ( = groupe de contrôle). L'elimination de salicylate n'était pas décisive pour la formation des groupes. De 1968 à 1972 le total des femmes NAPAP-positives a reculé de 50 % à 35 %. La diminution concerne presque exclusivement des femmes NAPAP-positives un ou deux jours, tandis que le nombre de femmes positives tous les trois jours restait stable. En même temps le nombre de femmes positives pour salicylate a diminué également. Des raisons possibles pour la tendance rétrograde de la consommation d'analgésiques sont mentionnées. L'élimination beaucoup plus fréquente de salicylate par le groupe d'étude en comparaison du groupe de contrôle est probablement due à la consommation d'analgésiques combinés. Les résultats provisoires de 1975 correspondent aux résultats précédents.
    Type of Medium: Electronic Resource
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