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  • 1
    Electronic Resource
    Electronic Resource
    Experimental study of the intra-ocular penetration of ketoconazole in rabbits (1987)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 225 (1987), S. 163-165 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied 11 healthy rabbits and 15 rabbits with experimentally inducedCandida endophthalmitis. Using a microbiological procedure, ketoconazole levels were determined 1, 2, 4, 8 and 24 h after its oral administration. Ketoconazole penetration was average in the aqueous humour, significant in tears and poor in the vitreous. Vitreous penetration was not detectable in healthy rabbits or in rabbits with chorioretinits exhibiting little or no vitreous reaction. Such penetration was only significant in rabbits exhibiting massive vitreous exudation; however, in such rabbits, penetration was not always observed (only in 2 out of 6 animals). Given these results, the treatment ofCandida endophthalmitis in humans using ketoconazole would appear to be of questionable value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02175442
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Etude histo-pathologique de la chorio-retine des prematurés (1966)
    Springer
    Documenta ophthalmologica 20 (1966), S. 420-440 
    Details
    ISSN: 1573-2622
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The authors examined histologically 38 eyes of premature newborns. Different alterations were observed: lax coaptation of the two retinal layers, vascular anomalies, lesions of the limitant membrane, which may be of some interest in connection with retrolental fibroplasia.
    Abstract: Zusammenfassung Die Autoren haben histologisch die hinteren Abschnitte von 38 Augen von Frühgeburten untersucht. Sie fanden verschiedene Veränderungen: Unregelmäßigkeit im Aneinanderpassen der beiden Netzhautblätter, Gefäßanomalien, Läsionen der Membrana limitans, die ein großes Interesse im Rahmen der retrolentären Fibroplasie haben.
    Notes: Résumé Les auteurs ont étudié au point de vue anatomo-pathologique le segment postérieur de 38 globes de prématurés. Ils ont observé des altérations diverses: laxité de coaptation des deux feuillets rétiniens, anomalies vasculaires, lésions de la membrane limitante intéressantes par leur valeur pathogénique dans le cadre de la fibroplasie rétrocristallinienne.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165432
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Candida endophthalmitis after heroin abuse (1985)
    Springer
    Mycopathologia 92 (1985), S. 73-76 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Three cases of ocular candidosis involving heroin abusers have been observed in 1983 in Toulouse department of ophthalmology. These three patients had used iranian brown heroin. Twenty similar cases have been published in these last years. This new pathology can be explained on two reasons. The first is that the drug abusers have some immunity pertubation; however, immunity exploration in these patients does not reveal any immunodeficiency. The second reason, certainly more important, is the method of using heroin. The diagnosis of Candida endophthalmitis of course based on clinical context must be proved by biological tests. Candida albicans is never identified in aqueous humor. For this reason, it seems very interesting to detect anti-candida antibodies in aqueous humor. It has been used as methods of dosage laser Nephelemetry for IgG and immunofluorescence for candidosis antibodies. The criterion used is similar to the toxoplasmosis coefficient established by Desmonts (3). In two cases, this test was the only way that permits us to have certitude of candidosis ocular diagnosis. Otherwise the observations show that anterior chamber punction is more significant when there is an anterior uveitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444086
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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