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  • 1
    Electronic Resource
    Electronic Resource
    The beneficial effects of oral nifedipine on cyclosporin-treated renal transplant recipients — a randomised prospective study (1996)
    Springer
    Transplant international 9 (1996), S. 115-125 
    Details
    ISSN: 1432-2277
    Keywords: Nifedipine, CyA, renal transplantation ; CyA, nifedipine, renal transplantation ; Renal transplantation, nifedipine, CyA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to test the hypothesis that nifedipine will improve graft survival in cyclosporin A (CyA)-treated renal transplant recipients. One hundred and forty-seven patients were randomised to one of three regimens. Group A received CyA, 7 mg/kg per day, and prednisolone; group B followed the same regimen as group A plus oral nifedipine and group C received CyA, 4 mg/kg per day, prednisolone and azathioprine. Calcium channel blockers were avoided in groups A and C. The crude 2-year (P=0.0223) and 4-year (P=0.0181) graft survival was significantly better in group B (86% and 81%, respectively) than in group A (75% and 63%, respectively). Delayed initial function was seen least frequently in group B (10.2%) compared to groups A (31%) and C (28%; P〈0.01). Group B also experienced fewer rejection episodes than groups A and C (P〈0.05). We conclude that the combination of oral nifedipine and CyA significantly improves initial graft function, rejection frequency and long term graft survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336388
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  • 2
    Electronic Resource
    Electronic Resource
    Arteriovenous fistulas for dialysis: Blood flow, viscosity, and long-term patency (1982)
    Springer
    World journal of surgery 6 (1982), S. 628-633 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A prospective study of the influence of blood flow at the time of operation on subsequent performance of dialysis fistulas is reported. Flow was measured in 33 consecutive arteriovenous fistulas using an electromagnetic flowmeter. During the mean follow-up time of 7 months (range, 2–12 months), 19 fistulas were used for dialysis, 9 have not yet been used, 4 were never used because of thrombosis or failure to develop adequately, and 1 patient died before using the fistula for hemodialysis. There were 9 complications (thrombosis, stenosis, and failure to develop). Operative blood flow for these 9 fistulas averaged 221 ml/min as compared to 214 ml/min for the group with no subsequent problems. No critical flow rate below which the fistula would not develop could be defined. An analysis of influences on flow rate at the time of operation showed that there was a significant correlation between flow and blood pressure, vessel dimensions, and whole blood viscosity, but it was not possible to predict fistula failure from these data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01657883
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lymphoblast transformation following adjuvant treatment of an induced colonic cancer with levamisole and fluorouracil (1982)
    Springer
    Cancer immunology immunotherapy 12 (1982), S. 267-271 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lymphoblast transformation (LT) in response to phytohaemagglutinin was measured following surgery in a dimethylhydrazine-induced colorectal tumour model in rats. Groups of normal rats were treated with levamisole (given either before and after surgery or only after surgery), fluorouracil (given after surgery), or a combination of both drugs (given either both together or with the administration of levamisole delayed 1 day after fluorouracil). A further untreated group acted as controls and the study was repeated with animals with colonic cancer. The administration of levamisole before surgery increased the restorative effect of postoperative levamisole. The effect was negated by fluorouracil given with levamisole, but not when levamisole was given 1 day after fluorouracil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199184
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of the development of modern vascular services on amputation rates in Leicester, U.K.: A preliminary report (1993)
    Springer
    Annals of vascular surgery 7 (1993), S. 102-105 
    Details
    ISSN: 1615-5947
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have reviewed 3036 consecutive patients who underwent arterial reconstruction, percutaneous transluminal angioplasty, or a major amputation for lower limb peripheral vascular disease in Leicester between 1974 and 1990. Patient data were obtained from the Hospitals Activity Analysis database, which codes all patient discharges according to diagnosis and treatment. During this 17-year study period, 1132 patients have undergone arterial reconstruction, 706 patients have undergone percutaneous transluminal angioplasty, and 1198 patients have undergone major amputation. The results show that the number of arterial reconstructions and angioplasties for lower limb arterial occlusive disease has increased over the last 17 years. The total amputation rate has decreased slightly during the period studied, but overall the decrease has not been significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02042667
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    Paper (German National Licenses)
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