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  • 1
    Electronic Resource
    Electronic Resource
    Response of fistulating Crohn's disease to infliximab treatment assessed by magnetic resonance imaging (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 17 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : To assess fistula track healing after infliximab treatment using magnetic resonance imaging.Methods : Magnetic resonance imaging and clinical evaluation were performed before and after three infliximab infusions given over a 6-week period. Magnetic resonance images were evaluated for abscesses and fistula tracks. Paired magnetic resonance image examinations were rated ‘better’, ‘unchanged’ or ‘worse’. Magnetic resonance imaging and clinical outcomes were then compared.Results : Of the 12 referred patients, pre-treatment magnetic resonance imaging detected abscesses in three (two not treated). Of the 10 treated patients, seven had peri-anal fistulas, two of whom also had recto-vaginal fistulas, and three had abdominal wall entero-cutaneous fistulas. After infliximab, four were in remission, one had a response and five were non-responders. One developed a peri-anal abscess. Magnetic resonance imaging improved in six, was unchanged in two and was worse in two. In four of the six with improvement in magnetic resonance imaging, the fistula track resolved, but two of these had clinically persistent entero-cutaneous fistulas. The clinical outcome and magnetic resonance imaging correlated in seven of the 10 patients; in three (two entero-cutaneous and one peri-anal), there was discordance.Conclusions : Magnetic resonance imaging identifies clinically silent sepsis. Fistulas may persist despite clinical remission. Clinical response to infliximab and clinical correlation with magnetic resonance imaging were poor in patients with abdominal entero-cutaneous fistulas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01427.x
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of 〈fr〉Helicobacter〈/fr〉 species in inflammatory bowel disease (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 18 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Bacteria have been implicated in the pathogenesis of inflammatory bowel disease. Helicobacter species have been shown to cause colitis in animal models and have been identified in human diarrhoeal illness and Crohn's disease.Aim: : To determine whether Helicobacter species are present in human inflammatory bowel disease tissue.Methods: : Thirty patients undergoing colonoscopy for clinical reasons were studied. Nine had Crohn's disease, 11 had ulcerative colitis and 10 had histologically normal colons. Tissue was snap-frozen at −70 °C. DNA was extracted and examined by five different polymerase chain reaction (PCR) assays that were either genus or species specific for Helicobacter.Results : Analyses of colonic biopsies by two Helicobacter genus-specific PCR assays, two H. pylori-specific assays and a PCR assay designed to amplify fragments of ‘H. heilmannii’-like organisms demonstrated that product was not generated by any test. Internal control PCR demonstrated that PCR results for the five assays were not negative due to the presence of residual substances inhibitory to PCR.Conclusions : Helicobacter species were not identified in this study, using multiple PCRs to eliminate the problems of non-specific cross-reaction. This suggests that Helicobacter species do not play a role in the pathogenesis of inflammatory bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01703.x
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  • 3
    Electronic Resource
    Electronic Resource
    Penicillin-allergic patients react to penicillin-modified “self” (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 44 (1989), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Penicillin G (PNG) has been demonstrated to elicit T-cell responsiveness in vitro in allergic patients by means of a lymphocyte transformation test (LTT). As it was not clear how, or in what form, the stimulatory PNG determinants were inducing cellular proliferation, we compared the immune response elicited by different PNG preparations. Peripheral blood lymphocytes (PBL) of patients with proven PNG allergy were isolated, and proliferative responsiveness to soluble PNG alone, soluble PNG-protein conjugates (BPO-HSA, BPO-PL, BPO-HEX), and non-reactive penicilloate salts, was evaluated. An autologous mixed lymphocyte culture (MLC) using penicilloylated stimulator cells, was used to test responsiveness to membrane-bound PNG. We found that the addition of either 1000 μg/ml of potentially-reactive PNG to cell cultures, or of penicilloylated autologous cells was stimulatory, whereas non-reactive PNG salt, and soluble PNG conjugates were not stimulatory. Considering current and earlier findings, it appears that T cell immunity in these patients is directed towards PNG-modified “self”, as PNG-modified autologous cells are potent stimulators in PNG-allergic individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1989.tb02262.x
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  • 4
    Electronic Resource
    Electronic Resource
    The clinical course of fistulating Crohn's disease (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 17 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To determine the clinical characteristics, management and outcome of Crohn's fistulas from the time of first presentation.Methods : Patients treated for fistulas 6 years previously were assessed for disease demographics, fistula characteristics and treatment from first presentation to final follow-up.Results : Eighty-seven patients with active Crohn's fistulas were evaluated. The median age was 35 years and the median duration of Crohn's disease was 8 years at study entry. Disease was ileo-colonic or colonic in 85%, and 65% had rectal involvement. A single fistula was present in one-third and multiple fistulas in two-thirds; 65% of fistulas were perianal; 80% of fistulas were complex. After a median follow-up from the last treatment of 5.9 years, 68% of patients showed healing of all fistulas, 18% showed healing of some fistulas and 14% showed no healing of fistulas. The fistula site did not influence healing. Perianal and recto-vaginal fistulas took a median of 2.6 years to heal. Half of the complex fistulas required a stoma, resection or proctectomy.Conclusions : Healing is usually achieved. However, morbidity is great and healing is slow. Proctectomy is required in one-fifth of patients, and perineal healing is often slow. Defining the perianal fistula anatomy as complex or simple determines the likelihood of healing and the type of surgical approach required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01561.x
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  • 5
    Electronic Resource
    Electronic Resource
    Milk whey-specific immune complexes in allergic and non-allergic subjects (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 43 (1988), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We developed an antigen- and isotype-specific ELISA for the rapid detection of native serum immune complexes (IC). It is a sandwich assay, in which a solid phase antigen-specific capture antibody selectively binds the auitigen-specific IC via the antigen. The isotype of the bound IC is then identified using an enzyme-labelled indicator antibody. Using this sensitive assay system, we were able to detect native serum milk whey-specific immune complexes (SMIC) of the IgG, IgE and IgA isotypes. Detectable amounts of native serum SMIC of all three isotypes were found in sera of the majority of both atopic and non-atopic subjects. The ELISA was then used to compare the levels of native IgE SMIC in sera of milk RAST positive atopic patients with those found in milk RAST negative atopic patient sera. Milk RAST positive patient sera were found to have significantly higher mean levels (P≥0.005) of native IgE SMIC than milk RAST negative sera. Sera of other atopic individuals were also found to contain significantly higher mean levels (P〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:01054538:ALL497:ges" location="ges.gif"/〉 0.005) of native IgG and IgA SMIC than non-atopic donors. IgE IC may specifically be involved in adverse symptoms seen in milk allergic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1988.tb01626.x
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  • 6
    Electronic Resource
    Electronic Resource
    Angular Size and Flux Density of the Small Source in the Crab Nebula at 81.5 Mc/s (1967)
    [s.l.] : Nature Publishing Group
    Nature 213 (1967), S. 1214-1216 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has proved difficult in observations at other frequencies, based on lunar occupations and interferometers of high resolving power, to recognize the contribution from this very compact component in the presence of other fine structure within the nebula. Further observations of interplanetary ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2131214a0
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  • 7
    Electronic Resource
    Electronic Resource
    Observation of a Rapidly Pulsating Radio Source (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 709-713 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Unusual signals from pulsating radio sources have been recorded at the Mullard Radio Astronomy Observatory. The radiation seems to come from local objects within the galaxy, and may be associated with oscillations of white dwarf or neutron ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/217709a0
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  • 8
    Electronic Resource
    Electronic Resource
    Observations of some further Pulsed Radio Sources (1968)
    [s.l.] : Nature Publishing Group
    Nature 218 (1968), S. 126-129 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Details are now given of three of the four pulsating radio sources discovered at ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/218126a0
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  • 9
    Electronic Resource
    Electronic Resource
    Observation of a Rapidly Pulsating Radio Source ( Reprinted from Nature, February 24, 1968) (1969)
    [s.l.] : Nature Publishing Group
    Nature 224 (1969), S. 472-472 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN July 1967, a large radio telescope operating at a frequency of 81-5 MHz was brought into use at the Mullard Radio Astronomy Observatory. This instrument was designed to investigate the angular structure of compact radio sources by observing the scintillation caused by the irregular structure of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/224472b0
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