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  • 1
    Electronic Resource
    Electronic Resource
    Localization of C4 genes within the HLA complex by molecular genotyping (1985)
    Springer
    Immunogenetics 21 (1985), S. 143-152 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Segregation of the complement component, C4, was analyzed in six families that each included an individual who inherited an HLA haplotype where a crossover event had occurred in the region between HLA-B and HLA-DR. Two cDNA clones corresponding to the C4 gene were utilized as probes in Southern blot analysis of DNA from members of each family. Restriction fragment length polymorphisms (RFLP) were observed and were assigned to haplotypes. In one family RFLP, hybridizing with the C4 probes, segregrated with HLA-B, and in four families RFLP segregated with HLA-DR; one family was not informative in this respect. These analyses have made it possible to localize the genes for C4 between HLA-B and HLA-DR by molecular genotyping and to characterize three different genomic configurations of C4 genes by limited restriction mapping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364866
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Partial characterization of human complement factor H by protein and cDNA sequencing: Homology with other complement and non-complement proteins (1986)
    Springer
    Bioscience reports 6 (1986), S. 65-72 
    Details
    ISSN: 1573-4935
    Keywords: complement ; factor H ; C4b-binding protein, C2, factor B ; β2-glycoprotein ; interleukin-2 receptor ; sequence homology ; cDNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Factor H, a control protein of the human complement system, is closely related in functional activity to two other complement control proteins, C4b-binding protein (C4bp) and complement receptor type 1 (CR1). C4bp is known to have an unusual primary structure consisting of eight homologous units each about 60 amino acids long. Such units also occur in the N-terminal regions of the complement proteins C2 and factor B, and in the non-complement serum glycoprotein β2I. Amino acid sequencing, and sequencing of a factor H cDNA clone, show that factor H also contains internal repeating units, and is homologous to the proteins listed above.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01145180
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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