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  • 1
    Electronic Resource
    Electronic Resource
    A benzodiazepine derivative and praziquantel: Effects on musculature of Schistosoma mansoni and Schistosoma japonicum (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 309-315 
    Details
    ISSN: 1432-1912
    Keywords: Benzodiazepine ; Praziquantel ; Schistosomes ; Cations ; Musculature ; Membrane transport of cations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The benzodiazepine derivative (Ro 11-3128) which has central nervous effects similar to other benzodiazepines, and praziquantel (PZ), are two new antischistosomal drugs. At low concentrations these drugs will produce a marked spastic paralysis of male Schistosoma mansoni musculature. An analysis of the action of these drugs on the parasite's musculature shows that Ro 11-3128 and PZ produced a rapid rise in the tension of the musculature of male schistomomes. Various compounds known to interact with the schistosome's neuroreceptive sites did not block or potentiate the action of these drugs. Removal of Ca2+ or addition of Mg2+ to the incubation medium blocked the action of these drugs on the schistosome's musculature. Uptake studies of inorganic cations by male schistosome's indicate that Ro 11-3128 and PZ decrease the influx of K+ but stimulate the influx of Ca2+ and Na+ into the male schistosome. It is suggested that this interference with inorganic ion transport mechanisms causes the contraction of the schistosome musculature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507974
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Psychosomatic relationships in ulceromembranous stomatitis (1940)
    Springer
    Psychiatric quarterly 14 (1940), S. 632-642 
    Details
    ISSN: 1573-6709
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary and Conclusions 1. During a three and one-half year period, ulceromembranous stomatitis was the most frequent remediable physical disease occuring among new admissions in the female division of the Creedmoor State Hospital. The incident rate was 6.5 per cent. 2. Psychosomatic relationships of this disease both before and after treatment have been discussed. 3. The usual methods of treatment were found to be varied, time-consuming and frequently ineffective. 4. Mapharsen applied in the manner outlined was the most convenient, economical and effective remedy used. No somatic injury was noted in patients under this treatment. 5. A routine method, applicable to institutions, for the detection and treatment of this disease has been described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01573144
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The relationship between tegumental disruption and muscle contraction inSchistosoma mansoni exposed to various compounds (1983)
    Springer
    Parasitology research 69 (1983), S. 61-71 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The antischistosomal drugs praziquantel and Ro 11-3128, which cause a tetanic contraction ofSchistosoma musculature, concurrently produce a disruption of the parasite's tegument. Both phenomena are attenuated by preincubation of the parasites in high Mg2+ containing media before addition of the drugs, and the therapeutically inactive stereoisomers of these drugs cause neither effect. Other antischistosomal drugs tested cause neither muscle contraction nor tegumental disruption. Some unrelated agents which cause muscle contraction (but have no antischistosomal effect) alter the parasite's tegument, while others do not. Cytochalasin B, but not colchicine, causes tegumental disruption without affecting muscle tension. Thus, there is no simple correlation between a drug's antischistosomal activity or ability to contract the parasite's muscle and its ability to damage the parasite's tegument.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00934011
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    Paper (German National Licenses)
    Fulltext
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