ISSN:
1432-2072
Keywords:
Diazepam
;
Benzodiazepines
;
Aged
;
Memory
;
Psychomotor performance
;
Buschke Selective Reminding Task
;
Plasma concentrations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Elderly normal volunteers (N=12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administration. Significant impairments were found in response to all doses of diazepam. The maximum impairment occurred at 1 h, which coincided with the highest plasma concentration of the drug.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00555210
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