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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 58 (1993), S. 7482-7489 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 21 (1983), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The Piper (1953) trilinear diagram has been widely used to graphically represent the dissolved constituents of natural waters and to test for apparent mixtures of waters from different sources. Because of the time required to plot points and calculate the proportional values of mixing, this treatment of data was often quite tedious, particularly in studies involving large numbers of chemical analyses. The PIPER program was written in BASIC to be run on a Hewlett-Packard desktop computer with an X-Y plotter. Data input is in ppm units. The program plots points in all three fields of the trilinear diagram, draws at each point within the central diamond field a circle with a radius correspondent to the concentrations expressed in meq/1, checks for points that fall on a straight line (or within a predetermined tolerance of a straight line) representing postulated mixtures with two end members, and/or within a triangle representing mixtures of three end members. Finally, the program does a numerical analysis of the mixing ratios of the constituents for postulated mixing systems according to the methodology as presented by Piper (1953).
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7373
    Keywords: HSV ; thymidine kinase ; ribonucleotide reductase ; viral vector ; anti-tumor effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus (HSV) mutants kill dividing tumor cells but spare non-proliferating, healthy brain tissue and may be useful in developing new treatment strategies for malignant brain tumors. Two HSV mutants, a thymidine kinase deficient virus (TK-) and a ribonucleotide reductase mutant (RR-), killed 7/7 human tumor cell lines in tissue culture. The TK-HSV killed Rat RG2 glioma and W256 carcinoma lines but not the rat C6 glioma in culture. TK-HSV replication (12 pfu/cell) was similar to wild-type HSV (10 pfu/cell) in rapidly dividing W256 cells in tissue culture, but was minimal (〈1 pfu/cell) in serum-starved cells, suggesting that the proliferative activity of tumor cells at the site and time of TK-HSV injection may influence efficacyin vivo. Subcutaneous W256 tumors in male Sprague-Dawley rats were injected with TK-HSV or virus free inoculum. A significant effect of TK-HSV therapy on W256 tumor growth was demonstrated compared to controls (p=0.002). Complete regression was observed in 4/9 experimental tumors, with no recurrence over 6 months. Tumor growth in the remaining 5/9 animals was attenuated during the first 3 to 5 days after treatment, but not beyond 5 days compared to 9 matched control animals; no tumor regression was observed in any of the control animals. These results suggest that HSV mutants are potentially useful as novel therapeutic agents in the treatment of tumors in immunocompetent subjects.
    Type of Medium: Electronic Resource
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