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  • 1
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Nasal polyposis (NP) is not a life-threatening disorder but may have a great impact on the quality of life (QoL). The objective of this study: (i) to investigate the health burden incurred by NP compared with the Spanish general population using the Short Form-36 Health Survey (SF-36) questionnaire; (ii) to compare the QoL outcome after medical or surgical treatment; and (iii) to assess and compare the effect of medical and surgical treatment on nasal symptoms.Methods:  About 109 patients with nasal polyps were included. Fifty-three patients were randomly allocated to receive oral prednisone for 2 weeks and 56 to undergo endoscopic sinus surgery. All patients administered intranasal budesonide for 12 months. Patients were evaluated for nasal symptoms, polyp size, and QoL.Results:  In comparison with the Spanish general population, patients with NP had worse scores on all SF-36 domains except for physical functioning. Nonasthmatic patients with NP had better QoL than asthmatic patients with NP on role physical functioning, body pain, and vitality (P 〈 0.05). At 6 and 12 months, a significant improvement on all of SF-36 domains was observed after both medical and surgical treatment reaching the levels of general population (P 〈 0.05). Nasal symptoms and polyp size improved after both medical and surgical treatment at 6 and 12 months (P 〈 0.05).Conclusion:  These results suggest that NP has considerable impact on a patient's QoL and that both medical and surgical treatment led to similar effects in improving QoL.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0458
    Keywords: Schlüsselwörter JNF ; Endoskopische NNH-Chirurgie ; Gefäßmißbildung ; Key words Juvenile nasopharyngeal angiofibroma ; Vascular malformations ; Endoscopic surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Current surgical approaches to juvenile nasopharyngeal angiofibromas (JNA) are exclusively external. This implies not only incisions that are mostly visible, but also a potential loss of function as well as secondary lesions and high perioperative risks. Radiotherapy aims to avoid surgery, but cannot exclude complications and possible sequelae. These consequences are commonly accepted as the ”costs” for both therapies, although neither is negligible. For both surgery and radiotherapy, recurrences or persistence rates have been described, so that outcome may result in questions for the treatment used as well as the complications or sequelae. We report our experiences with two cases of JNA operated on under endoscopic control and discuss our indications for the endoscopic approach to these tumors, preoperative conditions, surgical technique, and the possible difficulties of surgery and outcome. Our results encourage us to recommend use of endoscopic surgery as a valid alternative method to approach resections of certain JNA.
    Notes: Zusammenfassung Die chirurgischen Zugänge zur Exstirpation juveniler Nasen-Rachen-Fibrome (JNF) sind überwiegend extern. Dies bedeutet häufig die Notwendigkeit später sichtbarer Schnittführungen und u.U. auch potentielle Funktionsverluste, sekundäre Läsionen und erhöhte perioperative Risiken. Die publizierten Rezidivraten nach Eingriffen von JNF sind relativ hoch und sie gestatten es, die Indikation einer aggressiven Chirurgie zumindest für einige Fälle in Frage zu stellen. Die Strahlentherapie zielt darauf ab, einen Eingriff zu ersparen, sie kann jedoch weder Komplikationen noch Nebenwirkungen vermeiden. Es wird erstmals über 2 Fälle eines JNF berichtet, die einer endoskopischen Resektion unterzogen wurden, und es werden die Indikationen dieses schonenden Zugangs sowie seine technischen Besonderheiten diskutiert. Die vorläufigen Ergebnisse ermutigen uns, den endoskopischen Zugang als eine echte Alternative für den Eingriff von bestimmten JNF im Epipharynx hervorzuheben.
    Type of Medium: Electronic Resource
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