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Thrombin Interactions with Platelet Membrane Proteins (1986)

BERNDT, M. C. ; GREGORY, C. ; DOWDEN, G. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Annals of the New York Academy of Sciences 485 (1986), S. 0

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ISSN: 1749-6632

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Natural Sciences in General

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb34598.x

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Heparin-induced thrombocytopenia (1989)

Chong, B. H. ; Berndt, M. C.

Springer

Annals of hematology 58 (1989), S. 53-57

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ISSN: 1432-0584

Keywords: Thrombocytopenia ; Heparin anticoagulant therapy ; Complication

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Thrombocytopenia is a frequent and sometimes insidious complication of anticoagulant therapy with heparin. Two types of heparin-induced thrombocytopenia with a distinct aetiology have been recognized. Type I is characterized by a mild thrombocytopenia of early onset which requires careful monitoring but usually not the cessation of heparin therapy. The mild thrombocytopenia is probably due to the mild pro-aggregatory properties of heparin and can be more severe in the presence of other predisposing factors, e.g. sepsis. Type II heparin-induced thrombocytopenia is more severe and usually occurs after a period of 7–10 days. Heparin therapy should be ceased immediately and other anticoagulant therapy initiated. The thrombocytopenia is believed to be due to the development of a heparin-dependent antibody that causes platelet aggregation and release. The precise mechanism of heparin-dependent antibody-platelet interaction is still not entirely clear but probably involves the binding of an antibody-heparin immune complex to the platelet Fc receptor.