ISSN:
1432-1106
Keywords:
Dopamine
;
D-1 and D-2 agonists
;
Afterhyperpolarization
;
Hippocampal slices
;
Guinea pig
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In hippocampal pyramidal cells (HPCs), Dopamine (DA) application (1 μM) produced, in 50% of recorded cells, an hyperpolarization of the resting membrane potential (r.m.p.) and an increase of the afterhyperpolarization (AHP) amplitude and duration in 79% of recorded cells. DA-induced effects on both the r.m.p. and AHP were mimicked by bath application of a D-l selective agonist, SKF 38393 (20 μM). In addition, we have observed that a D-l selective antagonist such as SCH 23390 (1 μ,M) abolished the action of both DA and SKF 38393. In contrast, the activation of D-2 receptors through LY 171555 (10 μm) produced, in 50% of cells, a depolarization of the r.m.p. and a depression of the AHP in 67% of recorded cells. These results suggest that the effects observed in hippocampal pyramidal neurons after DA application of micromolar concentration are mediated by D-1 subtype of receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00232200
Permalink