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  • 1
    Electronic Resource
    Electronic Resource
    Surface morphology of mouse and rat thymic lymphocytes: An in situ scanning electron microscopic study (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 191 (1978), S. 203-219 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The present paper deals with a scanning electron microscopic investigation which was undertaken in order to make a direct study of geometrical conformations of thymocytes, to determine the effect of external mechanical forces and finally to analyse the relation of the cell surface morphology to the differentiation and release of thymocytes into circulation. Thymocytes in situ revealed a striking polyhedral configuration with distinct edges and angles that permit a close orientation of cells in a minimum space. This conformation is probably acquired under the influence of forces in the microenvironment of the cells. The immature thymocytes in the cortex were smooth surfaced and constituted a homogeneous population with regards to surface morphology except for slight variations in the size and angles of various facets of the polyhedra. A minority of the cell population occupying the medulla, however, exhibited a departure in possessing surface undulations and stubby protuberances. Thymocytes isolated in suspension and those in postcapillary venules of thymus did not show the polyhedral shape characteristic of the cells in thymic tissue. They were always rounded, with their surfaces often exhibiting undulations or microvilli The variations observed in situ are discussed in light of external mechanical forces, cell surface characteristics and the inherent properties of differentiating thymocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091910206
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of linoleic acid on capping, lectin mediated mitogenesis, surface antigen expression, and fluorescent polarization in lymphocytes and BHK cells (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 103 (1980), S. 399-406 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The incubation of linoleic acid with cells causes profound effects on membrane associated phenomenon. Using the fluorescent probe diphenyl hexatriene (DPH) to monitor lipid changes in the microenvironment of the cell surface, we find that linoleic acid reduces the polarization values (P) in mouse lymphocytes and BHK cells. Measurements on lipids extracted from the cells grown in linoleic acid produce similar results. We also find in the mouse lymphocyte that capping of Ig is inhibited and con A stimulated mitogenesis is unaffected. In contrast to the latter effect, LPS and PHA stimulated mitogenesis is inhibited and in the rat lymph node, con A stimulated mitogenesis, greatly enhanced. We also show that linoleic acid alters the binding of antibodies to the cell surface of EL-4 lymphoma cells. These observations suggest that linoleic acid alters cellular function by interfering with protein/lipid interactions within the surface membrane.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041030305
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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