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  • 1
    Electronic Resource
    Electronic Resource
    Potentiation of cochlear hair cell loss by acoustic stimulus and gentamicin in the guinea pig (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 230 (1991), S. 136-145 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: We explored the possibility of synergism between a pure-tone stimulus and gentamicin in causing cochlear injury by analyzing hair cell loss. Guinea pigs receiving daily injections of gentamicin (200 mg/kg body wt.) for 1 week were exposed to a 2 kHz tone (95 dB SPL, 2 hours daily). Surface preparations of the spiral organ were studied by phase contrast microscopy, and the extent of hair cell loss in the entire organ of Corti was recorded in cytocochleograms.Gentamicin by itself was slightly ototoxic, damaging the innermost row of outer hair cells, whereas exposure to sound alone caused no hair cell loss. Combined antibiotic and acoustic exposure produced extensive cochlear damage. A few animals showed massive hair cell degeneration and collapse of the organ of Corti, except in the apical turn. The site of damage was possibly determined by the frequency of the sound stimulus. Thus, an intermittent tonal stimulus such as that used in the present experiment can be harmless by itself, but causes injury to cochlear hair cells in guinea pigs when administered in combination with gentamicin.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092300114
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  • 2
    Electronic Resource
    Electronic Resource
    Histomorphic changes following chronic adrenocortical activation and inhibition in the pigeon (1970)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 130 (1970), S. 257-269 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Gravimetric and histologic modifications in the pigeon were studied following chronic therapy with ACTH and metopirone (SU 4885) for a period of 15 days. The organs studied were proventriculus, duodenum, heart, kidney, salivary gland, pancreas, liver, uropygial gland, thymus, spleen, bursa fabricii, testis, ovary, islets of Langerhans, adenohypophysis, thyroid and interrenal and chromaffin tissue of the adrenal gland. Induced states of hyper- and hypoadrenocorticalism elicited pathomorphic changes in endocrine and reproductive systems and some other organs of the pigeon. There were many differences and similarities in the nature of response of some organs following the two experimental conditions. Many of these cellular interactions might have resulted from alteration of interrenal function in the pigeon.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051300210
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cellular modification of interrenal tissue induced by corticoid therapy and stress in three avian species (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 133 (1972), S. 483-493 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Corticotropic regulation of the interrenal tissue was explored in three avian species (quail, parakeet and myna) by application of dexamethasone therapy and stress. In response to corticoid administration, atrophy of all cortical layers from periphery to center was pronounced and no regional differences could be detected by histology and histometric analysis. Following exposure to acute formalin stress at the termination of chronic corticoid therapy, the interrenal tissue regularly responded by hypertrophy in all three types of birds. The absence of zonation in experimental atrophy in these species merits consideration in view of the zonal response observed in other avian species. The prompt response of the atrophic interrenal gland to stress indicates that the hypothalamo-hypophyseal regulation of the interrenal gland is qualitatively different from mammals.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001330409
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution and structure of the adrenocortical homologue in the garpike (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 160 (1981), S. 231-246 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The microanatomy of the yellow corpuscles (adrenocortical homologue, AH) in the holostean fish, Lepisosteus spp., was studied by serial sectioning, steroid histochemistry, and electron microscopy. The modification of this tissue to short-term ACTH treatment was also observed. The distribution of the AH within the renal tissue of the garpike phylogenetically represents a more advanced condition than that seen in its closest holostean relative, the bowfin, and appears to approximate that in teleosts. The homology of this tissue to vertebrate adrenocortical tissue was established by the positive identification of the enzyme, Δ5-3β-hydroxysteroid dehydrogenase, and by the ultrastructural features of the cells before and after ACTH administration.The AH cells possess fine structural features characteristic of steroidogenic cells, namely, polymorphic mitochondria with tubular cristae, abundant tubules of smooth endoplasmic reticulum, a prominent Golgi complex, and lipid droplets. Other interesting features include the presence of annulate lamellae and a variety of dense bodies. Digitonin perfusion results in the deposition of presumed, cholesterol-digitonide crystalline spicules on the surface microplicae of the cells and as dense accumulations in association with smooth endoplasmic reticulum. ACTH administration results in swelling of mitochondria, a loss of their cristae, and a decrease in electron density of their matrices. Alterations also occur in the smooth and rough endoplasmic reticulum, and large osmiophilic inclusions of irregular profile appear. Some of the ACTH-induced modifications are similar to those observed in the adrenocortical cells of other vertebrate groups following comparable stimulation.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001600302
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