ISSN:
1432-0428
Keywords:
Insulin-dependent diabetes mellitus
;
free radicals
;
cytokines
;
beta-cell destruction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2 − and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00400830
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