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  • 1
    Electronic Resource
    Electronic Resource
    Subthalamic stimulation influences postmovement cortical somatosensory processing in Parkinson's disease (2003)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 18 (2003), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In Parkinson's disease, poor motor performance (resulting primarily from abnormal cortical activation during movement preparation and execution) may also be due to impaired sensorimotor integration and defective cortical activity termination of the ongoing movement, thus delaying preparation of the following one. Reduced movement-related synchronization of the beta rhythm in Parkinson's disease compared to controls has been put forward as evidence for impaired postmovement cortical deactivation. We assessed the effects of subthalamic deep brain stimulation and l-dopa on beta rhythm synchronization over the premotor and primary sensorimotor cortex. Ten advanced patients performed self-paced wrist flexion in four conditions according to the presence or not of stimulation and l-dopa. Compared to without treatment, the motor score improved by ≈ 60%; the beta synchronization was present over the contralateral frontocentral region and increased significantly over the contralateral central region under stimulation and under l-dopa, with a maximal effect when both treatments were associated. Our advanced patients displayed very focused and attenuated beta rhythm synchronization which, under stimulation, increased over the contralateral premotor and primary sensorimotor cortex. Stimulation and l-dopa both partly restored postmovement cortical deactivation in advanced Parkinson's disease, although the respective mechanisms probably differ. They may improve bradykinesia and cortical deactivation by reestablishing movement-related somatosensory processing at the end of the movement through the basal ganglia into the cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2003.02925.x
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  • 2
    Electronic Resource
    Electronic Resource
    503 Estradiol and progesterone cytosolic receptors in 18 intra-cranial tumors
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 19 (1983), S. 172 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(83)92004-6
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  • 3
    Electronic Resource
    Electronic Resource
    Stereotactically guided radiosurgery using the linear accelerator (1993)
    Springer
    Acta neurochirurgica 124 (1993), S. 40-43 
    Details
    ISSN: 0942-0940
    Keywords: Radiosurgery ; convergent multibeam irradiation ; arteriovenous malformations ; intracranial tumours ; stereotactic irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Leksell initiated the concept of stereotactic radiosurgery in 1951. This last decade has seen a rapid proliferation in the development of the methodology which is certainly related in part to the simultaneous growth of high-resolution neuro-imaging techniques. By focusing the beams of 201 hemispherically arrayed cobalt 60 sources, the gamma-knife delivers a high dose of radiation to a small target. Another possibility proposed by several authors is the bragg peak cyclotron-generated irradiation with accelerated protons or helium ions. In Lille, since 1988, we have choosen to develop stereotactic radiosurgery, according to the system of Betti, by the association of Talairach's stereotactic methodology and external single-dose encephalic irradiation with high energy X-rays, delivered by means of a linear accelerator. The major indication for the use of this method is an arteriovenous malformation. Stereotactic radiosurgery may be proposed alone or in combination with surgery and embolisation. It has been shown to be a potentially effective treatment and an attractive alternative in carefully selected patients with intracranial tumours: slow-growing, well limited, deep-seated tumours, such as some gliomas, acoustic neurinomas, skull base meningiomas, pituitary adenomas. This treatment is also used to deliver a focal boost of radiation to previously administered fractionated radiotherapy in patients with small gliomas and solitary brain metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400715
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  • 4
    Electronic Resource
    Electronic Resource
    A frameless method for 3D MRI- and CT guided stereotaxic localisation (1992)
    Springer
    European radiology 2 (1992), S. 35-41 
    Details
    ISSN: 1432-1084
    Keywords: Stereotaxy ; Neurosurgery ; Medical imaging ; Treatment planning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract MR and CT are well recognized as the best imaging procedures for localisation in stereotaxic neurosurgery. However special difficulties necessitate specific adaptation to: localise targets in the steriotaxic frame. A method using MR and CT images is presented: no special frame must be. used during imaging examinations, but only the four intracranian holders of the neurosurgical stereotaxic frame. The images data are transferred to: a PC-based system for 3D localisation of brain targets. By locating the four markers on the images, the transformation matrices can be computed to: obtain the coordinates of a lesion in the stereotaxic space. The system calculates the arc setting parameters of a probe trajectory to: the target, either for an orthogonal or a double oblique approach if needed. Simulated probe trajectory intersections with the consecutive slices can be viewed in order to: validate the trajectory before the surgical procedure. The systematic geometrical errors have been carefully evaluated. Original procedures and corrective algorithms have been implemented as well as checks to: detect geometrical distortion or movements made by the patient. In this way, millimeter accuracy is achieved in the three dimensions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00714179
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  • 5
    Electronic Resource
    Electronic Resource
    Serial stereotactic biopsies and CT scan in gliomas: correlative study in 100 astrocytomas, oligo-astrocytomas and oligodendrocytomas (1987)
    Springer
    Journal of neuro-oncology 4 (1987), S. 317-328 
    Details
    ISSN: 1573-7373
    Keywords: stereotactic biopsies ; gliomas ; CT scanning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histologic features of 100 supra-tentorial astrocytomas, oligodendrogliomas and oligo-astrocytomas obtained from serial stereotactic biopsies were compared with the corresponding CT scans. Topographic comparisons provided by visualization of the biopsy trajectories on post-biopsy CT scans were available in 24 cases. Areas of contrast enhancement and low attenuation were compared with the histologic grade of malignancy, tumor delimitation and structural type. The latter was determined as follows: Type I-solid tumor tissue without significant peripheral isolated tumor cells; Type II-solid tumor tissue associated with peripheral isolated tumor cells; Type III-isolated tumor cells only. There was a strong correlation between areas of contrast enhancement and tumor microvascularity. In addition, contrast enhancement occurred only in the solid tumor tissue component of the neoplasm. This correlation accounted for the relationship observed between CT images and the structural type of glioma. Contrast enhancement was constant in structural type I gliomas, inconstant in structural type II, and absent in structural type III. No correlation was found between malignancy and contrast enhancement. Contrast enhancement occurred in all grades of malignancy but was a constant feature of grade 4 gliomas. The volume of the tumors could not be reliably determined from CT images alone. Areas of low attenuation on contrast CT scans could correspond to either peritumoral edema or to edematous parenchyma infiltrated by isolated tumor cells. Serial stereotactic biopsies combined with calculations based on the CT scan provided a more precise definition of the tumor volume and identification of structural type. Such classification may prove useful in prospective analysis of various modes of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195602
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