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  • 1
    Electronic Resource
    Electronic Resource
    Porphyrin concentrations in various human tissues (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 4 (1995), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract We measured the concentrations of total porphyrins and their metabolites (uro-, hepta-, hexa-, penta-, copro- and protoporphyrin) in various human tissues: liver, erythrocytes, skin, adipose tissue, and mammary gland. The porphyrin concentrations varied within minor limits, e.g., 3.1 ±2.3 nmol porphyrins/g liver and 0.50±0.10 nmol/g erythrocytes. No significant differences were detectable in other tissues in comparison with liver. In all tissues, the predominant metabolite was protoporphyrin, followed by coproporphyrin, whereas only low concentrations of higher carboxylatcd porphyrins such as uroporphyrin were detectable. It is concluded that porphyrin metabolism and its regulation is similar in all human tissues, perhaps with some small differences in the erythrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1995.tb00248.x
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of topical photodynamic therapy with 5-aminolevulinic acid on porphyrin metabolism (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 517-521 
    Details
    ISSN: 1432-069X
    Keywords: Key words Photodynamic therapy ; 5-Aminolevulinic ; acid ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Photodynamic therapy (PDT) with topically applied 5-aminolaevulinic acid (5-ALA) is increasingly used for treating tumours. The efficacy of topical PDT is limited to superficial and initial tumours. The topically applied doses of 5-ALA vary from 0.02 to 7.0 g per session according to the type of lesion. There are no studies on the influence of topically applied 5-ALA on the systemic accumulation of porphyrins or porphyrin precursors. A group of 20 patients with actinic keratoses (AK) and basal cell carcinomas (BCC) were treated by topical PDT with 5-ALA. Prior to and 6 and 24 h after PDT, 5-ALA and total porphyrin concentrations were determined in red blood cells and plasma, respectively. In addition, before and after 5-ALA treatment, 24-h urine samples were collected and porphyrins and porphyrin precursors were measured. There was no significant alteration in porphyrin metabolism. In some patients, a slight but insignificant increase in erythrocyte and plasma porphyrins was found 6 h after 5-ALA PDT. This investigation confirms clearly the safety of this treatment modality and demonstrates that 5-ALA application (up to 7 g) in the course of PDT has no influence on the concentrations of porphyrins and porphyrin precursors measured in various compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050095
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Einfluß von Chloroquin auf die Hexachlorbenzol-induzierte Porphyrie (1980)
    Springer
    Archives of dermatological research 267 (1980), S. 123-130 
    Details
    ISSN: 1432-069X
    Keywords: Porphyria ; Porphyrins ; Hexachlorobenzene ; Chloroquine treatment ; Iron metabolism ; Porphyrie ; Porphyrine ; Hexachlorbenzol ; Chloroquinbehandlung ; Eisenstoffwechsel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei weiblichen Ratten wurde durch Applikation von 0,05% Hexachlorbenzol (HCB)-Futterzusatz eine Porphyrie erzeugt. Anschließend wurden die Tiere über maximal 6 Wochen zusätzlich mit Chloroquin (CQ) (50 mg/kg/Tag) behandelt und mit entsprechenden Kontrollgruppen verglichen. CQ bewirkte eine etwa 50%ige Senkung der Porphyrinausscheidung im Urin und des Porphyringehaltes in Leber und Haut gegenüber HCB-Kontrollen. Das relative Porphyrinverteilungsmuster wurde durch CQ nicht beeinflußt. In einem weiteren Experiment erhielten Ratten von Versuchsbeginn an simultane Gaben von CQ und HCB. Die CQ-Prophylaxe bewirkte eine signifikant verzögerte Porphyriemanifestation. Auf Grund der Ergebnisse schließen wir, daß bei der HCB-bedingten Porphyrie der Ratte der Wirkmechanimus des CQ nicht nur auf der Bildung eliminierungsfähiger CQ-Porphyrin-Komplexe beruht. Es wird vielmehr angenommen, daß durch CQ eine Beeinflussung des Eisenstoffwechsels vorliegt, die die Porphyrinstoffwechselstörung abschwächt.
    Notes: Summary Rats were fed with a diet containing hexachlorobenzene (HCB) for about 60 days. At this time the porphyria was manifest as shown by significantly elevated porphyrins. Thereafter, chloroquine (CQ) was additionally given over a period of at least 6 weeks. At the end of the experiment the urinary porphyrin excretion and the porphyrin content in liver and skin were diminished in HCB-CQ-treated animals by about 50% compared to the HCB controls. The relative porphyrin distribution pattern was not influenced by CQ. In a further investigation the prophylactic effect of CQ could be demonstrated. Rats given CQ simultanously from the beginning of the HCB feeding showed a significantly delayed onset of porphyria. It is concluded from our results that CQ does not only form complexes with porphyrins during the treatment of the HCB porphyria. We rather assume an effect of CQ on the metabolism of iron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569098
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