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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 488 (1986), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1569-8041
    Keywords: computed tomography ; gallium scan ; magnetic resonance ; mediastinal Hodgkin's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In patients with Hodgkin's disease, the use of gallium-67scintigraphy (Ga-67) compared to conventional staging and restaging techniquesis still controversial. In particular, in a combined modality treatment withchemotherapy and radiotherapy given in sequence, its role in detecting activedisease after chemotherapy may be useful in planning the subsequentradiotherapeutic strategy. Patients and methods: From March 1990 to September 1994, 125 patientswith previously untreated histologically proven Hodgkin's disease wereenrolled in two different prospective trials according to clinical stage.Staging procedures included Ga-67, chest-abdominal computed tomography (CT),and/or magnetic resonance (MR). All three tests were performed in 53patients at staging and in 47 at restaging. Results of Ga-67 at staging werecompared to conventional procedures or pathological findings. Results ofGa-67, CT scan, and MR at restaging were compared to disease outcome duringthe follow-up. Finally a cost/benefit ratio for each test was determined. Results: At staging, Ga-67 showed lower sensitivity than CT and MR(90 vs. 96 and 100%, respectively) because of the number offalse-negative images. Nevertheless, by using both CT and Ga-67 scan, thesensitivity is equal to that observed with MR (100%). At restaging,Ga-67 is superior to CT scan and equivalent to MR in detecting true negativepatients (specificity: 98% vs. 45% vs. 92%). Conclusions: As a single technique, Ga-67 scan cannot substitute forCT scan or MR in staging patients with Hodgkin's disease. Nevertheless, Ga-67scan has an important role in defining complete remission after treatment andtherefore in planning subsequent treatment. Considering the lower costs of CTscan plus Ga-67 ($320) versus MR alone ($810), the twotests may be considered procedures of choice in staging as well as inrestaging patients with Hodgkin's disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 549-559 
    ISSN: 1432-1335
    Keywords: Keywords PET ; FDG ; Uptake mechanism ; Malignancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over the past decades, Positron Emission Tomography has opened a new field of imaging. Nowadays, this technique is being used for diagnosing, staging disease as well as for prognostic stratification and monitoring therapy. In this respect, [18F]fluorodeoxyglucose (FdGlc) is by far the most commonly used PET agent. Many factors have been identified being responsible for a high uptake of this agent in malignancy. However, additional factors such as tumour treatment may interfere with the uptake mechanism. Knowledge of all these factors is a prerequisite for an optimal interpretation of PET studies and, consequently, for a reliable judgement of tumour status. In this article, a review is given of the factors influencing FdGlc uptake and the implications for clinical studies.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1569-8041
    Keywords: advanced disease ; aromatase inhibitors ; breast cancer ; formestane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In postmenopausal breast cancer (BC) patients, tamoxifen (TAM)is frequently used in first-line therapy, and for those relapsing under TAM,aromatase inhibitors would be the drug of choice. Formestane, a new aromataseinhibitor, has been demonstrated to be as effective as TAM in first-linetherapy. This trial was carried out to investigate the pharmacokinetics andantitumor activity of two formestane doses in BC patients at first relapse,as well as their effects on estrogen levels, evaluated by means of a newanalytical method. Patients and methods: One hundred fifty-two postmenopausal BC patients wererandomly given formestane 250 mg or 500 mg intramuscularly every two weeks.The blood samples for estrogen measurements were taken on the first day oftherapy, at 4 and 10 weeks, and every 12 weeks thereafter. Tumor response wasfirst evaluated after 2.5 months, and then every three months. Results: Seventy-three patients received formestane 250 mg and 79 received500 mg. After four weeks, plasma estrone, estradiol and estrone sulphatelevels were significantly (P〈0.001) suppressed in both groups. The overallresponse rates were 30% and 40% on 250 mg and 500 mg,respectively. Conclusions: Both of the formestane doses are effective in reducing plasmaestrogen levels in BC patients at first relapse, and the new analytical methodimproved the quality of results. The antitumor response was highlysatisfactory.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1619-7089
    Keywords: Key words: Technician dose ; Positron emitters ; Fluorine-18 fluorodeoxyglucose ; Positron emission tomography ; Nuclear medicine procedures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to determine the non-extremity gamma dose received by a technician while performing an ordinary nuclear medicine procedure or a static (i.e. without blood sampling) fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) study. The dose per patient was measured by means of a commercial electronic pocket Geiger Mueller dosimeter, worn in the upper left pocket of the overalls. This was previously tested by exposure to known point sources of technetium-99m, gallium-67, iodine-131 and fluorine-18 in the air. A further test was performed with 99mTc, 131I and 18F sources inserted in a water phantom to simulate the condition of high scattering degradation of the primary radiation due to the patient’s tissues. Subsequently, the dose was measured by two technicians for a total of 314 clinical cases, covering the most common nuclear medicine procedures, including 44 static, two-level FDG PET studies with repositioning of the patient on the couch between the transmission and the emission scan and seven whole-body PET studies. The dose read by the dosimeter was corrected for environmental background and for detector efficiency measured with sources in the air. For a limited subset of cases, the time spent close to patients was also measured. Doses were then estimated by a crude non-absorbing point source approximation and by using experimental dose rates. A comparison between experimental and estimated doses, as well as with previously published data, completed the work. For most of the conventional procedures, the measured dose per procedure proved to be within the range 0.2–0.4 μSv, except for equilibrium angiocardioscintigraphy (1.0±0.5 μSv) and 99mTc-sestamibi single-photon emission tomography (1.7±1.0 μSv). Comparison with data published in the last 20 years shows that our values are generally lower. The current more favourable working conditions are a result of technological improvements (for instance two-head gamma cameras capable of whole-body studies), and safer shielding and distance from patients. Two-level PET gave 11.5±4.4 μSv and whole-body PET 5.9±1.2 μSv. In a subset of patients these values could be subdivided into the separate contributions from each phase of the procedure. They were: 0.11±0.04 μSv for daily quality assurance, 2.9±3.0 μSv for two transmission scans, 0.3±0.1 μSv for syringe preparation, 2.8±1.8 μSv for injection and escorting the patient to the waiting room, 1.7±1.5 μSv for a whole-body emission scan, 7.7±5.2 μSv for two emission scans, and 0.8±0.2 μSv for patient departure. The higher value from PET by comparison with conventional procedures is attributable to the higher specific gamma constant of 18F, as well as the longer time required for accurate positioning.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1590-3478
    Keywords: Thymidine kinase ; neuron specific enolase ; markers ; brain tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Abbiamo studiato l'attività di due enzimi NSE e TK nei liquidi biologici di 104 Pazienti affetti da patologie del sistema nervoso. I Pazienti sono stati divisi in quattro gruppi: dei 35 Pazienti affetti da neoplasie 20 erano portatori di un tumore della serie gliale. Su liquor e su siero il valore cut-off dell'attività di NSE e TK è stato fissato al 95o percentile del gruppo controllo. Lo scopo del nostro studio è stato quello di stabilire la affidabilità del dosaggio della NSE e della TK nel separare i tumori cerebrali da altre patologie d'interesse neurologico. Nei nostri Pazienti la maggiore attività enzimatica al di sopra del valore cut-off è stata riscontrata nel gruppo tumorale. I livelli serici di TK sembrano essere un utile marker per la valutazione del follow-up post-chirurgico dei Pazienti affetti da tumore gliale, mentre la valutazione dei valori della NSE non sembra utile a tale scopo.
    Notes: Abstract We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups. 20 subjects out of 35 in the tumor group had glial tumors. We fixed a cut-off value of NSE and TK activity at the 95th percentile of the control group, both in serum and in CSF. The aim of our investigation was to assess the reliability of TK and NSE assays in separating brain tumors from other neurological diseases. In our patients, most of the TK activity above the cut-off value was found in the tumor group. Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, “one-pot” reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.
    Type of Medium: Electronic Resource
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