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  • 1
    Electronic Resource
    Electronic Resource
    Simultaneous optimization of response variables in protein mixture formulation: constrained simplex method approach (2003)
    Oxford, UK : Blackwell Science Ltd
    International journal of food science & technology 38 (2003), S. 0 
    Details
    ISSN: 1365-2621
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The objective of this study was to test a complex constrained simplex, direct search, sequential method for the optimization of a ternary mixture of protein ingredients used in a formulation for the preparation of a milk drink regularly consumed in institutional nutritional programmes. Three proteins [hydrolysed gelatine (HG), wheat gluten (WG) and soybean protein isolate (SPI)] were mixed according to a simplex-centroid design, in order to explore the possible synergies between the sensory, nutritional and economic attributes. Mixtures containing different proportions of the three ingredients were submitted to sensory, nutritional and economic evaluations. All responses were modelled using Scheffé's canonical equations. A microinformatics application was developed in order to permit optimization to be computed. The optimum solution obtained by this non-linear programming was HG = 20%, WG = 27% and SPI = 53%, suggesting that the program is efficient and flexible enough for multiresponse optimization. The optimal point behaviour of the entry variables (HG, WG and SPI) can be monitored with graphs of the trace plot type, in which the proportion of two variables is fixed and the third is allowed to vary in relation to the desired response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2621.2003.00650.x
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  • 2
    Electronic Resource
    Electronic Resource
    Acquired haemophilia: experience of two Italian centres with 17 new cases (1997)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 3 (1997), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Acquired haemophilia is a rare but often catastrophic haemorrhagic disorder associated with a high mortality rate. No single therapeutic approach has been consistently successful and clinical experience remains mainly anecdotal. This report describes 17 new cases diagnosed at two Italian haemophilia centres between 1979 and 1995.There was no difference in sex distribution. Mean age at diagnosis was 50 years. Fifty-nine per cent of cases had associated disorders and 29% developed an inhibitor post-partum. Eleven (64%) patients required substitutive therapy. Desmopressin was successfully used in five cases for minor bleeding. Immunosuppressive drugs (steroid, cyclophosphamide or experimental therapy) were used in 14 (82%) cases. Eight of 15 (52%) evaluable cases achieved complete remission (four post-partum). Fatal haemorrhage occurred in 2/15 (13%) of patients within 2 days from diagnosis.Acquired haemophilia is a severe coagulopathy. Prompt diagnosis with characterization and intensive treatment is usually required. However, particular subsets of patients such as those with inhibitor occurring post-partum or with low inhibitor titre at diagnosis usually show a more favourable clinical outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.1997.00102.x
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  • 3
    Electronic Resource
    Electronic Resource
    Die Lage der Wissenschaftstheorie in Ungarn (1973)
    Springer
    Journal for general philosophy of science 4 (1973), S. 133-146 
    Details
    ISSN: 1572-8587
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Zusammenfassung In der vorliegenden Studie berichten die Verfasser über die Lage der Wissenschaftstheorie in Ungarn. Nach einem kurzen historischen Überblick sichten sie die heutigen Forschungsrichtungen der ungarischen Wissenschaftstheorie. In diesem Zusammenhang befassen sie sich mit wissenschaftsphilosophischen Forschungen überhaupt, des weiteren mit den Studien zur Analyse von bürgerlichen wissenschaftstheoretischen Richtungen und mit den wissenschaftstheoretischen Fragen neuer Disziplinen und Forschungszweige. Mit besonderer Aufmerksamkeit verfolgen die Autoren die Aktivitäten zur Untersuchung der aufkommenden wissenschaftlich-technischen Revolution und der einschlägigen Forschungen. Ausführlich sind auch die Forschungsarbeiten in den Einzelbereichen der Wissenschaftslehre: Wissenschaftslogik,— Methodologie,— Soziologie usw. dargestellt. Des weiteren erörtert die Abhandlung auch die Zusammenhänge, die sich zwischen den wissenschaftlichen Forschungen und anderen gesellschaftlichen Aktivitäten — Politik, Technik, Künste, Informationswesen, Pädagogik usw. — ergeben. Abschließend informiert die Studie über die Forschungsstellen, die sich in Ungarn mit wissenschaftstheoretischen Arbeiten befassen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01801069
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  • 4
    Electronic Resource
    Electronic Resource
    Veröffentlichungen ungarischer Wissenschaftstheoretiker (1973)
    Springer
    Journal for general philosophy of science 4 (1973), S. 188-193 
    Details
    ISSN: 1572-8587
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Nature of Science, Research, Systems of Higher Education, Museum Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01801072
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  • 5
    Electronic Resource
    Electronic Resource
    Successful pregnancy in a woman with congenital factor XIII deficiency treated with substitutive therapy (1987)
    Springer
    Annals of hematology 55 (1987), S. 45-48 
    Details
    ISSN: 1432-0584
    Keywords: Factor XIII deficiency ; Recurrent abortion ; Pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A syndrome of marked fetal wastage is associated with congenital factor XIII deficiency in adult women. A previously unreported case of a woman with factor XIII deficiency is described, in which substitutive treatment with normal plasma or placental factor XIII concentrate permitted two normal pregnancies. Factor XIII activity was maintained above 1–2% with intermittent infusion of 300 ml to 450 ml of plasma every 14 days or of 500 units of concentrate every 21 days. This case confirms the only other case so far reported in which factor XIII substitutive therapy was able to permit a normal pregnancy in a woman with factor XIII deficiency and seems to suggest factor XIII to be involved in the process of annidation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319641
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical effectiveness of desmopressin in a case of acquired von Willebrand's syndrome associated with benign monoclonal gammopathy (1989)
    Springer
    Annals of hematology 58 (1989), S. 211-213 
    Details
    ISSN: 1432-0584
    Keywords: Acquired von Willebrand's syndrome ; DDAVP ; Desmopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of acquired von Willebrand's syndrome (avWs) secondary to benign monoclonal gammopathy, is described, in which desmopressin (DDAVP) has proven effective repeatedly in preventing bleeding after tooth extraction. The laboratory pattern was similar to that of congenital type IA von Willebrand's disease. After DDAVP, prolonged bleeding time and factor VIII/von Willebrand factor activities were normalized. The disappearance rate of the elicited activities was similar to that observed in patients with congenital disease. This report adds to the scarce data concerning the haemostatic effectiveness of DDAVP in avWs and suggests that this agent might also be used in controlling or preventing bleeding in patients with the acquired disease, selected on the basis of their biological responsiveness to a test-infusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320776
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  • 7
    Electronic Resource
    Electronic Resource
    Development of brain damage after neonatal hypoxia-ischemia: Excitatory amino acids and cysteine (1996)
    Springer
    Metabolic brain disease 11 (1996), S. 109-123 
    Details
    ISSN: 1573-7365
    Keywords: Neonate ; hypoxia-ischemia ; cysteine ; neurotoxicity ; sulfur-containing amino acids ; excitatory amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate the possible role of excitatory amino acids (EAAs) and cysteine in the development of brain damage after hypoxia-ischemia (HI) in neonates. In a rat model of neonatal HI, changes in extracellular (ec) amino acids in cerebral cortex were measured with microdialysis and correlated with the extent of brain damage at the site of probe placement. Extracellular concentrations of glutamate, aspartate and cysteine increased during HI and remained elevated during reperfusion. During HI the pattern of EAA changes was the same in the infarcted, undamaged and border zone regions. During reperfusion, however, the ec concentrations of glutamate, aspartate and cysteine were higher in infarcted and border zone areas compared to undamaged tissue. HI also produced a slight increase of tissue concentration of cysteine and decrease of tissue concentration of glutamate in parietal cortex of the HI hemisphere. The effect of cysteine on brain damage induced by HI and glutamate was also investigated. A subtoxic dose of cysteine potentiated glutamate toxicity in the arcuate nucleus and enhanced brain infarction after HI in neonatal rats. The results show that in neonatal HI the extracellular levels of EAAs during HI are not directly related to brain injury but the EAA levels during reflow predict the extent of infarction. Cysteine increases HI-induced brain injury and potentiates glutamate toxicity in neonatal rats. Speculatively, elevated level of cysteine during reperfusion may participate in the excitotoxic cascade leading to brain injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02069499
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