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  • 1
    Electronic Resource
    Electronic Resource
    Decreased Hepatic 5-Aminolevulinate Dehydrase in Experimental Hemochromatosis (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 526 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb55530.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Role of Cytochrome P-450 in Porphyria Caused by Halogenated Aromatic Compounds (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 514 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb48765.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Frequency and distribution of DNA fragmentation as a marker of cell death in chronic liver diseases (1997)
    Springer
    Virchows Archiv 431 (1997), S. 189-194 
    Details
    ISSN: 1432-2307
    Keywords: Key words Apoptosis ; Liver disease ; Hepatitis ; Hepatocytes ; Kupffer cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To study the early stages of cell death in various types of chronic liver injury, liver biopsies from a total of 26 patients, including 7 with chronic hepatitis C(CHC), 4 with chronic hepatitis B(CHB), 7 with alcoholic liver disease (ALD), 4 with autoimmune or drug hepatitis(AI/DH), and 4 with primary biliary cirrhosis(PBC), were examined by an in situ nucleotidyl transferase assay (ISNTA), which detects DNA fragmentation. Positive nuclei in hepatocytes and sinusoidal lining cells were counted in all parenchymal areas, excluding triads and areas of fibrosis, using a computer with Sigmascan software. The number of positive hepatocytes/mm2 was similar in the biopsies of patients with CHC, CHB, ALD and AI/DH, but significantly lower in PBC. The number of positive sinusoidal lining cells/mm2 was significantly greater in biopsies with CHC compared to CHB, ALD, AI/DH and PBC. Double staining revealed that the ISNTA-positive sinusoidal lining cells were also CD68 positive, indicating that they were Kupffer cells. The frequency of ISNTA positivity did not correlate with serum AST or ALT levels, steatosis, cell swelling or cirrhosis. ISNTA-positive hepatocytes were more frequent than acidophilic bodies in every disease category. We conclude that apoptosis may be a common pathway of cell death in different liver diseases, that the high frequency of DNA fragmentation in Kupffer cells in CHC suggests that during chronic hepatitis C infection activated Kupffer cells may be subject to regulatory control by apoptosis and that ISNTA is more sensitive than acidophilic bodies in assessing the degree of cell injury in the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050087
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of heme oxygenase in intestinal epithelial cells: studies in Caco-2 cell cultures (1993)
    Springer
    Molecular and cellular biochemistry 129 (1993), S. 93-98 
    Details
    ISSN: 1573-4919
    Keywords: biliverdin reductase ; Caco-2 cells ; heme ; heme oxygenase ; intestinal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Enterally administered, heme is a good source of iron in humans and other animals, but the metabolism of heme by enterocytes has not been fully characterized. Caco-2 cells in culture provide a useful model for studying cells that resemble small intestinal epithelium, both morphologically and functionally. In this paper we show that heme oxygenase, the rate-controlling enzyme of heme catabolism, is present in abundance in Caco-2 cells, and that levels of its mRNA and activity can be increased by exposure of the cells to heme or metal ions (cadmium, cobalt). Caco-2 cells also contain biliverdin reductase activity which, in the basal state, is similar to that of heme oxygenase (approximately 40 pmole of product per mg protein per minute); however, when heme oxygenase is induced, biliverdin reductase may become rate-limiting for bilirubin production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926580
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  • 5
    Electronic Resource
    Electronic Resource
    Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: Evidence against a stress-mediated response (1997)
    Springer
    Molecular and cellular biochemistry 169 (1997), S. 13-20 
    Details
    ISSN: 1573-4919
    Keywords: heme oxygenase ; stress response ; metalloporphyrin ; liver cell culture ; antioxidants ; protein synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Heme oxygenase catalyzes the first and rate-controlling step in heme catabolism. One of the two forms of heme oxygenase (heme oxygenase-1) has been shown to be increased by heme, metals, and in some systems, by certain environmental stresses. However, it remains uncertain whether heme induces hepatic heme oxygenase-1 by a general stress response, or a specific heme-dependent cellular response. The work communicated here explores this issue by examining possible mechanisms whereby heme and other metalloporphyrins induce heme oxygenase-1 in normal liver cells. Primary cultures of chick embryo liver cells were tested for their ability to increase heme oxygenase mRNA after exposure to selected metalloporphyrins (heme, chromium mesoporphyrin, cobalt protoporphyrin and manganese protoporphyrin). The ability of antioxidants to decrease metalloporphyrin-mediated induction of heme oxygenase-1 mRNA was also tested. Our results indicate that: 1) the increase in heme oxygenase-1 mRNA mediated by heme or other metalloporphyrins may involve a short-lived protein(s) since the increase was prevented by several inhibitors of protein synthesis; and 2) in normal liver cells, heme-dependent oxidative stress does not play a key role in the heme-mediated induction of heme oxygenase-1. We conclude that heme and other non-heme metalloporphyrins induce heme oxygenase-1 through a mechanism requiring protein synthesis, not because metalloporphyrins increase cellular oxidative or other stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006817207166
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  • 6
    Electronic Resource
    Electronic Resource
    High-dose interferon-α2b for re-treatment of nonresponders or relapsing patients with chronic hepatitis C (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 149-154 
    Details
    ISSN: 1573-2568
    Keywords: chronic hepatitis ; hepatitis C ; interferon therapy ; adverse side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Relatively few patients with chronic hepatitis C treated with standard doses of interferon-α2b (3 million units per week for 24 weeks) have a sustained response. Our aim was to evaluate whether higher doses of interferon would improve this rate of response. Twenty-four patients with chronic hepatitis C who had failed to respond to (N=21) or had relapsed after (N=3) an initial course of standard interferon therapy were randomized to 15 million units (N=13) or 22.5–30 million units per week (N=11) for 24 weeks. Five of 13 subjects given 15 million units per week and 3/11 of subjects given 22.5–30 million units per week had complete normalization of serum alanine aminotransferase levels during therapy. Five patients (24%) who had not responded to standard interferon had a complete response to high-dose interferon during therapy. Only one patient had a sustained response, with normal serum alanine aminotransferase 24 weeks after stopping interferon. Six patients were withdrawn before completing treatment, five in the 22.5–30 million unit per week group. We conclude that higher doses of interferon ameliorate the severity of hepatitis in patients who failed to respond to or relapsed after standard interferon therapy, but are unlikely to produce a sustained response. High-dose therapy is associated with an increase in side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208597
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