ISSN:
1432-1041
Keywords:
theophylline
;
metabolism
;
1,3-dimethyl uric acid
;
excretion
;
age dependency
;
tubular reabsorption
;
children
;
3-methylxanthine
;
1-methyluric acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The renal clearance of theophylline (TH) and its metabolites 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine (3-MX), and 1-methyluric acid (1-MU) has been studied in 10 children aged 8 months to 14 years. Individual renal clearances were calculated from serum levels and amounts excreted in urine after i.v. administration of the parent drug. The clearance of 1,3-DMU was found to depend both upon urine flow rate and age, which are interrelated. An effect of urinary pH was expected, but was not studied. Consistent age-dependent changes in the relative quantities of metabolites excreted were not observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609186
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