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  • 1
    Electronic Resource
    Electronic Resource
    Experimental Allergic Sialoadenitis (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 6 (1977), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The right parotid duct of rats was instilled five to eight times with bovine serum albumin at daily intervals. Acute parotitis developed in non-sensitized animals, while chronic destructive sialoadenitis ensued in preimmunized rats. The morphological changes were reminiscent of those found in the salivary glands of patients with Sjögren's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1977.tb01636.x
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental allergic sialoadenitis (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 2 (1973), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. The parotid gland and knee joint of immunized rats were challenged with the sensitizing antigen. Sialoadenitis developed in over half of these rats after one and three challenges via the parotid duct. On the other hand, most glands were normal after five, seven and eight intraductal challenges in spite of the presence of precipitating antibodies in the scrum and hemagglutinating antibodies in the parotid saliva; in only a few animals did chronic destructive adenitis ensue. This contrasted with the incidence and severity of synovitis, which increased with the number of intra-articular injections of antigen. The non-reactivity of the gland is antigen specific in as much as acute adenitis resulted from intraductal instillation of a second antigen following multiple challenges with another one in rats sensitized with two antigens. The results evince a difference in the local reactivity between the salivary gland and synovial membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1973.tb01669.x
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  • 3
    Electronic Resource
    Electronic Resource
    Experimental allergic gingivitis (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 12 (1977), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunized and non-immunized rats were given 6 or 8 intragingival injections of bovine serum albumin or saline at intervals of 7, 3, 2 or 1 days. Biopsies of the gingiva were ob tained one day after the last challenge. The severity of inflammation in the oral mucosa decreased with increasing intervals between injections. Gingivitis did not develop in con trol rats, the mucosa of which was punctured 8 times without injection of solution. It is suggeseed that intragingival challenges give rise to the appearance of inhibitory factors, which are operative only when injections are administered at long spaced intervals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1977.tb00144.x
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  • 4
    Electronic Resource
    Electronic Resource
    Experimental allergic sialoadenitis. VII (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 4 (1975), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Rats were passively immunized by an intraperitoneal injection of homologous anti-BSA serum and their salivary glands were challenged 20 min or 24 hours later with BSA by the intraductal route. Immune complex sialoadenitis developed only when challenge was early. It is concluded that immunoglobulins are transferred from the circulation into the salivary glands and are relatively rapidly cleared by a mechanism yet unknown, possibly by salivary flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1975.tb01735.x
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental allergic gingivitis (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 9 (1974), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One to eight injections of BSA or saline were given into the gingiva of sensitized or nonsensitized rats. The mucous membrane of untreated rats was found to be mildly inflamed. A single injection of BSA or saline caused moderate to severe gingivitis. The severity and incidence of gingivitis decreased with increasing number of injections of BSA or saline into the mucosa. This phenomenon of induced “local non-reactivity” is similar to that observed in the parotid gland after multiple introductions of antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1974.tb00691.x
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  • 6
    Electronic Resource
    Electronic Resource
    Observations on the species-nonspecificity of the human renal and placental basement membrane antigens (1963)
    Springer
    Cellular and molecular life sciences 19 (1963), S. 517-518 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Kaninchenantisera, mit Antikörpern gegen Basalmembranantigene menschlicher Niere und Plazenta, wurden, bei Anwendung der Coonsschen fluoreszierenden Antikörpermethode zur Bestimmung von heterogenen Antigenen in vier anderen Spezies, angewandt. Es wurde nachgewiesen, dass die glomerulären und tubulären Basalmembrane der Meerschweinchen- und Mausniere ein oder mehrere Antigene enthalten, welche mit Antihumannierenserum und Antihumanplazentaserum eine Kreuzreaktion zeigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150885
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  • 7
    Electronic Resource
    Electronic Resource
    Alpha-fetoprotein and liver cell proliferation in rats fed choline-deficient diet (1976)
    Springer
    European journal of nutrition 15 (1976), S. 211-216 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Der3H-Thymidin-Aufnahmeindex in der Leber und das Serum AFP wurden bei Ratten, welche bei einer standardisierten Laboratoriumsdiät oder mit einer Cholinmangeldiät ernährt wurden, bestimmt. Es wurde festgestellt, daß die Proliferation der Leberzellen bei Tieren, die die Mangeldiät erhalten haben, signifikant erhöht war. Weiterhin wurde bei einigen dieser Ratten eine erhöhte Serumkonzentration des AFP gefunden. Die Befunde deuten darauf hin, daß die vermehrte Synthese des AFP einer Leberzellregeneration, welche sekundär zu einem Leberschaden entsteht, entspricht.
    Notes: Summary Liver3H-thymidine labelling index and serum AFP were determined in rats fed a standard laboratory or choline deficient diet. A significant increase in the rate of liver cell proliferation was evidenced in animals on the deficient diet. Furthermore, elevated serum AFP levels were detected in a proportion of these rats. It is suggested that increased synthesis of AFP corresponds to liver cell regeneration secondary to hepatic damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02018443
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  • 8
    Electronic Resource
    Electronic Resource
    Acinar cell hydropic degeneration induced by intraductal instillation of solutions into the parotid glands of the rats (1977)
    Springer
    Virchows Archiv 374 (1977), S. 63-69 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Saline or BSA were instilled 2, 5, 8 or 11 times at daily intervals into the parotid glands of rats, via Stensen's duct. Hydropic change of the acinar cells developed after 8 and 11 instillations. Histologically, the lesion was characterized by enlargement of the acinar cells, the cytoplasm of which contained vacuoles displacing the nuclei. In view of the negative results of various histochemical reactions the vacuolization was interpreted as hydropic in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430570
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  • 9
    Electronic Resource
    Electronic Resource
    Experimental allergic sialoadenitis (1972)
    Springer
    Virchows Archiv 355 (1972), S. 213-219 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Verursachung einer akuten Sialoadenitis durch Instillation von normalem menschlichen Plasma in die Ohrspeicheldrüse spezifisch überempfindlich gemachter Ratten. Die Sialoadenitis war histologisch gekennzeichnet sowohl durch akut-entzündliche Infiltrate als auch durch Destruktion des Parenchyms. Alle sensibilisierten Ratten verfügten über präcipitierende Antikörper, aber nur eine Minderzahl zeigte eine Überempfindlichkeit vom verzögerten Typus. Es wird vermutet, daß an Ort und Stelle gebildete Antigen/Antikörperkomplexe eine Überempfindlichkeitsreaktion vom Arthus-Typus auslösen.
    Notes: Summary Acute sialoadenitis was induced by instillation of normal human plasma into the parotid gland of specifically sensitized rats. Histologically, the sialoadenitis was characterized by an acute inflammatory infiltration and parenchymatous destruction. All rats had precipitating antibodies, but less than half exhibited delayed skin reactivity. It is suggested that antigen-antibody complexes formed in situ elicit an Arthus-type of reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00551057
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  • 10
    Electronic Resource
    Electronic Resource
    The bivalence of Juxtaglomerular cells in the maturing rat kidney (1978)
    Springer
    Virchows Archiv 378 (1978), S. 111-120 
    Details
    ISSN: 1432-2307
    Keywords: Juxtaglomerular apparatus ; Granularity of afferent arterioles ; Immunofluorescence of contractile protein ; Maturation of kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A comparative immunofluorescence and light microscopical study of the three cell types of the Juxtaglomerular apparatus (pure muscle cells, pure granular cells and mixed cells) was performed on the growing and maturing kidney of the rat. Mixed cells, containing contractile protein and secretory granules, are detectable on the first postnatal day in about one third of the JGAs. From the third week, the number of bivalent cells increases, while the proportion of pure muscle or pure granular cells decreases. Morphological and functional maturation, achieved by 3 to 4 weeks, is associated with increasing numbers of bivalent cells and a shift in the main site of renin production from the inner to the outer cortical zone. The divergent internal structure of JGA cell types expresses the range of varied differentiation expressed by one cell line. Pure muscle or granular cells are at the extremes of the range and mixed cells take up an intermediate position.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432355
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