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  • 1
    Electronic Resource
    Electronic Resource
    Keratin Protein In Human Prostatic Tissue and Cell Culture (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 455 (1985), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1985.tb50459.x
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  • 2
    Electronic Resource
    Electronic Resource
    Prostate pathology case study seminar (1997)
    Springer
    Virchows Archiv 430 (1997), S. 83-94 
    Details
    ISSN: 1432-2307
    Keywords: Prostate ; Prostatic intraepithelial neoplasia ; Atypical adenomatous hyperplasia ; Basal cell proliferations ; Postatrophic hyperplasia Verumontanum mucosal gland hyperplasia ; Stromal hyperplasia with atypia ; Duct adenocarcinoma ; Mucinous adenocarcinoma ; Androgen deprivation Finasteride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Great strides have been made in the past decade in our understanding of the pathology of the prostate. Diagnostic criteria have been proposed, debated, and refined for a number of entities, including prostatic intraepithelial neoplasia, atypical adenomatous hyperplasia, basal cell proliferations, postatrophic hyperplasia, verumontanum mucosal gland hyperplasia, and numerous new variants of prostatic adenocarcinoma such as ductal adenocarcinoma, mucinous carcinoma, signet ring cell carcinoma, and lymphoepithelioma-like carcinoma. This report presents a series of case studies in prostate pathology which illustrate some of the contemporary issues which confront the pathologist and urologist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008021
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluating radical prostatectomy specimens: Therapeutic and prognostic importance (1997)
    Springer
    Virchows Archiv 430 (1997), S. 1-16 
    Details
    ISSN: 1432-2307
    Keywords: Prostate ; Prostatic neoplasms ; Staging Surgery ; Pathology ; Radical ; Prostatectomy Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pathologic staging of prostate cancer involves determination of the anatomic extent and burden of tumor based on the best available data. Proper examination of radical prostatectomy specimens is critical in determining cancer stage, stratifying patient need for adjuvant treatment, and prediction of patient outcome. Differences exist in methods of handling and sampling specimens, although publication of practice protocols in recent years has led to convergence of opinion. In this report, we evaluate the current aspects of pathologic staging of prostate cancer and assessment of prostatectomy specimens. Recent international agreement on pathologic staging of prostate cancer should allow valid comparisons of surgical treatment from different institutions. The vanishing cancer phenomenon is also briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008010
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  • 4
    Electronic Resource
    Electronic Resource
    Dysplasia and cancer complicating strictures in ulcerative colitis (1990)
    Springer
    Digestive diseases and sciences 35 (1990), S. 349-352 
    Details
    ISSN: 1573-2568
    Keywords: ulcerative colitis ; strictures ; dysplasia ; cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have found a widely variable prevalence of dysplasia and cancer in colonic strictures in patients with ulcerative colitis. Consequently, therapeutic recommendations are conflicting. To better assess the prevalence, we reviewed the clinical and pathological findings in all 27 patients with ulcerative colitis complicated by stricture who were entered into our Inflammatory Bowel Disease Registry. A true stricture was defined as a persistant localized narrowing of the colon found on air-contrast barium enema or on colonoscopy. Upon careful review, 12 of 27 patients were found to have transient colonic spasm, not a stricture, and were excluded. The remaining 15 patients with true strictures represented 3.2% of all ulcerative colitis patients in the registry. Strictures were identified at 13.3± 9.9 years following the diagnosis of ulcerative colitis. Eleven patients had multiple strictures that were principally located in the left colon. Of the 15 patients, 11 had dysplasia and two had cancer found on colonoscopic biopsy. Ultimately, six patients had carcinoma found at colonoscopy or colectomy (three modified Dukes' stage A, one stage B, and two stage D). All cancers were at the site of a stricture. These findings indicate that a true colonic stricture in ulcerative colitis is frequently associated with dysplasia and cancer, which can be diagnosed with colonoscopic biopsy. A stricture should be considered a strong risk factor for cancer, requiring intensive colonscopic surveillance. If dysplasia is discovered, or if the stricture cannot be adequately biopsied, consideration should be given to total colectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537413
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  • 5
    Electronic Resource
    Electronic Resource
    Humoral hypercalcemia complicating adenosquamous carcinoma of the proximal colon (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 142-147 
    Details
    ISSN: 1573-2568
    Keywords: hypercalcemia ; adenosquamous carcinoma ; colon carcinoma ; calcium ; carcinoma ; cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypercalcemia as a complication of carcinoma of the colon is uncommon (1). It usually occurs in the presence of anorectal or rectal carcinoma that metastasizes to the lumbosacral vertebrae (2–4). Hypercalcemia complicating colon carcinoma in the absence of bone metastases—so-called humoral hypercalcemia of malignancy or paraneoplastic hypercalcemia—is rare. Only two such cases associated with adenocarcinoma of the colon (5, 6) and two cases associated with adenosquamous carcinoma of the distal colon (rectum and sigmoid) (7) have been reported. We describe the first reported case of an adenosquamous carcinoma of the cecum and ascending colon that was accompanied by severe humoral hypercalcemia. The hypercalcemia was associated with a parathyroid hormone (PTH) -like substance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536171
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  • 6
    Electronic Resource
    Electronic Resource
    Isolated granulomatous gastritis in an adolescent (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 292-296 
    Details
    ISSN: 1573-2568
    Keywords: gastritis ; granulomatous gastritis ; Crohn's disease ; sarcoidosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This is a case of a 14 1/2-year-old black male with isolated granulomatous gastritis. The case is unusual in several aspects. For the first time this disorder has been seen in the pediatric age group. The symptoms and signs were more acute and severe than previously reported, and the inflammatory process involved the entire gastric mucosa. Several findings suggested an (auto)immune pathogenesis. The patient had a good clinical and histologic response to prednisone therapy, but the disease recurred after two years when therapy was discontinued.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536065
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  • 7
    Electronic Resource
    Electronic Resource
    Premalignant and early malignant lesions of the prostate (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 50 (1992), S. 9-9 
    Details
    ISSN: 0730-2312
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240501204
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  • 8
    Electronic Resource
    Electronic Resource
    Prostatic intraepithelial neoplasia (PIN) and other prostatic lesions as risk factors and surrogate endpoints for cancer chemoprevention trials (1996)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 63 (1996), S. 156-164 
    Details
    ISSN: 0730-2312
    Keywords: carcinogenesis ; chemoprevention ; prostate cancer ; prostatic intraepithelial neoplasia ; prostatic neoplasms ; surrogate endpoint biomarkers ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The most efficient strategy for chemoprevention clinical trials are short-term studies which focus on surrogate endpoint biomarkers (SEBs) in high-risk target populations. High-grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostate cancer, and is found in a significant number of routine contemporary needle biopsies without cancer. The frequency and extent of PIN are decreased with androgen deprivation therapy, suggesting that it is a suitable endpoint biomarker for modulation. Potential SEBs for screening chemopreventive agents for prostate cancer in short-term Phase II trials include (1) histologic premalignant lesions, such as high-grade PIN; (2) biochemical markers, including prostate-specific antigen (PSA) serum concentration; and (3) morphometric markers, including nuclear texture, shape, and roundness; size and number of nucleoli; and number of apoptotic bodies; (4) proliferation markers, including MIB-1 and PCNA; (5) genetic markers, including nuclear DNA content (ploidy), oncogene c-erbB-2 (HER-2/neu) expression, fluorescence in situ hybridization for chromosome 8; and PSA-producing cells in the blood detected by reverse transcriptase polymerase chain reaction; and (6) differentiation markers, such as microvessel density as a determinant of angiogenesis. Each of these endpoint biomarkers is measured easily and accurately in serum or in tissue specimens such as formalin-fixed, paraffin-embedded needle biopsies, and may be modifiable by intervention. The clinical utility of these biomarkers as modulatable endpoints in prostate cancer chemoprevention needs to be demonstrated in future clinical trials. J. Cell. Biochem. 25S:156-164. © 1997 Wiley-Liss, Inc.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Premaliganant and early malignant lesions of the bladder (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 50 (1992), S. 30-30 
    Details
    ISSN: 0730-2312
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240501306
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  • 10
    Electronic Resource
    Electronic Resource
    Natural history of early bladder cancer (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 50 (1992), S. 31-38 
    Details
    ISSN: 0730-2312
    Keywords: bladder ; carcinoma in situ ; dysplasia ; invasion ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Non-invasive transitional cell carcinoma (TCC) occurs as two distinct growth patterns, papillary and non-papillary (flat), which display significant differences in biologic potential. Papillary carcinoma usually presents as a low-grade lesion which frequently recurs multiple times prior to invasion; conversely, non-papillary (flat) carcinoma in situ is usually high-grade at presentation (carcinoma in situ) and frequently associated with invasion. These lesions may occur together, although papillary cancer is more easily visualized cystoscopically due to its exophytic growth; flat carcinoma in situ is often vystoscopically invisible.This report reviews existing data concerning the prognostic value of pathologic grading and staging of non-invasive and early invasive TCC. Emphasis is placed on those studies reporting surgical treatment rather than other forms of treatment. © 1992 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240501307
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