ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Myxoviruses injected intradermally into rats provoked activation of capillary endothelium, vasodilatation, increased capillary permeability, edema formation and severe disruption of the capillary wall without mastcell disruption, as visualized by the transparent skin techniques. Minute amounts of histamine and other stimuli, applied at the same site of the skin, further aggravated the vascular response to viruses and disrupted the perivascular mast cells. Neuraminidase, N-acetyl neuraminic acid, hyaluronidase and hyaluronic acid had a similar effect on the minute vessels, but there was no mast-cell disruption when histamine was injected at the same sites. Nasal discharge collected from a vasomotor rhinitis case, had no damaging effect on the capillaries. Nasal discharge from common cold cases, collected during the first three days of the onset provoked the same vascular damage as the myxoviruses. Samples collected at later periods did not effect the morphology of the capillaries. Vascular damage produced by the myxoviruses was not inhibited by levomepromazine, butazolidin or hydrocortisone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01250144
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