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  • 1
    Electronic Resource
    Electronic Resource
    Molecular technologies for biodiversity evaluation: Opportunities and challenges (1997)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 15 (1997), S. 625-628 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Better information on the degree and distribution of genetic variation is essential for developing more efficient ways of evaluating and conserving biodiversity. At present, an array of molecular techniques is available to detect diversity at the DNA level1, but the application of these ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0797-625
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  • 2
    Electronic Resource
    Electronic Resource
    A New Method for Locating Changes in a Tree Reveals Distinct Nucleotide Polymorphism vs Divergence Patterns in Mouse Mitochondrial Control Region (2000)
    Springer
    Journal of molecular evolution 50 (2000), S. 224-231 
    Details
    ISSN: 1432-1432
    Keywords: Key words: Phylogeny — Nucleotide change location — Base composition — Mouse — Mitochondrial control region — Polymorphism — Divergence — Test of neutrality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. A new, model-based method was devised to locate nucleotide changes in a given phylogenetic tree. For each site, the posterior probability of any possible change in each branch of the tree is computed. This probabilistic method is a valuable alternative to the maximum parsimony method when base composition is skewed (i.e., different from 25% A, 25% C, 25% G, 25% T): computer simulations showed that parsimony misses more rare → common than common → rare changes, resulting in biased inferred change matrices, whereas the new method appeared unbiased. The probabilistic method was applied to the analysis of the mutation and substitution processes in the mitochondrial control region of mouse. Distinct change patterns were found at the polymorphism (within species) and divergence (between species) levels, rejecting the hypothesis of a neutral evolution of base composition in mitochondrial DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002399910025
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  • 3
    Electronic Resource
    Electronic Resource
    Speciation and paraphyly in western mediterranean hares (Lepus castroviejoi, L. europaeus, L. granatensis, andL. capensis) revealed by mitochondrial DNA phylogeny (1994)
    Springer
    Biochemical genetics 32 (1994), S. 423-436 
    Details
    ISSN: 1573-4927
    Keywords: mitochondrial DNA ; phylogeny ; paraphyly ; Lepus, speciation ; polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Mitochondrial DNA (mtDNA) variation among specimens of the northwestern African hare (Lepus capensis schlumbergeri) and three European hares sampled in Spain (L. castroviejoi andL. granatensis, which are endemic to the Iberian Peninsula, andL. europaeus) was analyzed using seven restriction endonucleases. Fourteen haplotypes were found among the 34 animals examined. Restriction site maps were constructed and the phylogeny of the haplotypes was inferred. mtDNA ofL. capensis was the most divergent, which is consistent with its allopatric African distribution and with an African origin of European hares. We estimated that mtDNA in hares diverges at a rate of 1.5–1.8% per MY assuming that the European and African populations separated 5–6 MYBP. Maximum intraspecies nucleotide divergences were 1.3% inL. capensis, 2.7% inL. castroviejoi, and 2.3% inL. granatensis but 13.0% inL. europaeus. The latter species contained two main mtDNA lineages, one on the branch leading toL. castroviejoi and the other on that leading toL. granatensis. The separation of these two lineages from theL. castroviejoi orL. granatensis lineages appears to be much older than the first paleontological record ofL. europaeus in the Iberian peninsula. This suggests that the apparent polyphyly ofL. europaeus is due not to secondary introgression, but to the retention of ancestral polymorphism inL. europaeus. The results suggest thatL. europaeus either has evolved as a very large population for a long time or has been fractionated. Such a pattern of persistence of very divergent lineages has also been reported in other species of highly mobile terrestrial mammals. As far as mtDNA is concerned,L. europaeus appears to be the common phylogenetic trunk which has diversified during dispersion over the European continent and from whichL. castroviejoi andL. granatensis speciated separately in southwest Europe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566063
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  • 4
    Electronic Resource
    Electronic Resource
    New assays for Y Chromosome and p53 pseudogene clines among East Holstein house mice (1997)
    Springer
    Mammalian genome 8 (1997), S. 279 -281 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003359900410
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  • 5
    Electronic Resource
    Electronic Resource
    The musculus-type Y Chromosome of the laboratory mouse is of Asian origin (1992)
    Springer
    Mammalian genome 3 (1992), S. 84-91 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mus musculus domesticus, M.m. bactrianus, M. m. musculus, M.m. castaneus, and M.m. molossinus wild mice were investigated for polymorphisms of the Y Chromosome (Chr) genes Zinc finger-Y (Zfy) and Sex-determining region-Y (Sry). Zfy divided the Y Chrs of these mice into domesticus- (domesticus) and musculus-types (musculus, castaneus, molossinus). M.m. bactrianus specimens had both Y Chrs, possibly owing to the introgression of a musculus-type Y into this population. Sry identified a subpopulation of musculus-type Y chromosomes. This subpopulation, designated the molossinus-type, was found in M.m. molossinus, a M. musculus subspecies specimen from northern China (Changchun), and laboratory mice. The cumulative data suggest that M.m. musculus of northern China and Korea are subpopulation distinct from M.m. musculus of Europe and central China and that this subpopulation invaded Japan, giving rise to M.m. molossinus. Furthermore, the data suggest that the musculus-type Y of the laboratory mouse originated from this subpopulation, corroborating early historical record reporting that Chinese and Japanese mice that were imported into Europe for the pet trade contributed to the genome of the laboratory mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431251
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