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  • 1
    Electronic Resource
    Electronic Resource
    Distal-less encodes a homoeodomain protein required for limb development in Drosophila (1989)
    [s.l.] : Nature Publishing Group
    Nature 338 (1989), S. 432-434 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The normal development of Drosophila limbs depends on the activity of the Distal-less (Dll) gene. Several mutations that reduce, but do not completely eliminate, Dll activity permit survival to adulthood but cause developmental abnormalities in the adult limbs3. Examination of the effects of these ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/338432a0
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Sp1/egr-like zinc-finger protein required for endoderm specification and germ-layer formation in Drosophila (1994)
    [s.l.] : Nature Publishing Group
    Nature 369 (1994), S. 664-668 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Germ-layer formation in Drosophila begins by two major gastrulation movements once the homogeneous sheet of cellular blastoderm is established6. Ectoderm and mesoderm separate by the formation of the ventral furrow, a row of cells covering the ventral-most position of the embryo ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/369664a0
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mesoderm-specific B104 expression in the Drosophila embryo is mediated by internal cis-acting elements of the transposon (1995)
    Springer
    Chromosoma 103 (1995), S. 669-675 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Drosophila melanogaster genome contains about 100 copies of the B104 transposable element, which is strongly expressed during embryogenesis. Here we show that B104 expression is restricted to the esophageal and amnioproctodeal regions of the embryo and to the developing mesoderm. Mesoderm-specific B104 expression requires the activity of the mesoderm-determining factors twist and snail. Virtually the same expression patterns were observed in Drosophila yakuba, a species that a separated from D. melanogaster by some 15 million years of evolution. We show that B104 expression is directed by internal sequences of the retrotransposon that are capable of acting as a cis-acting regulatory element in front of a heterologous Drosophila promoter. Our findings suggest that retrotransposon insertions can affect the expression patterns of endogenous genes by adding and distributing specific cis-acting control elements throughout the host genome. We therefore propose that transposable elements in addition to reducing the fitness of their hosts may also provide a rich pool of cis-acting sequences that contribute to the long-term evolutionary potential of the population in a beneficial manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344227
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Mesoderm-specific B104 expression in the Drosophila embryo is mediated by internal cis-acting elements of the transposon (1995)
    Springer
    Chromosoma 103 (1995), S. 669-675 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The Drosophila melanogaster genome contains about 100 copies of the B104 transposable element, which is strongly expressed during embryogenesis. Here we show that B104 expression is restricted to the esophageal and amnioproctodeal regions of the embryo and to the developing mesoderm. Mesoderm-specific B104 expression requires the activity of the mesoderm-determining factors twist and snail. Virtually the same expression patterns were observed in Drosophila yakuba, a species that a separated from D. melanogaster by some 15 million years of evolution. We show that B104 expression is directed by internal sequences of the retrotransposon that are capable of acting as a cis-acting regulatory element in front of a heterologous Drosophila promoter. Our findings suggest that retrotransposon insertions can affect the expression patterns of endogenous genes by adding and distributing specific cis-acting control elements throughout the host genome. We therefore propose that transposable elements in addition to reducing the fitness of their hosts may also provide a rich pool of cis-acting sequences that contribute to the long-term evolutionary potential of the population in a beneficial manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344227
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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