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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 209-209 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Infection 3 (1975), S. 174-174 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Infection 3 (1975), S. 78-82 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden Lymphozyten von 22 mit chronischer Hepatitis befallenen Kindern mit 32 gesunden gleichaltrigen Kindern im Hinblick auf die DNA-Stimulierung, die E-Rosetten-Bildung und das Membran-Immunglobulin verglichen. Es ergab sich folgendes: Die Kurve der PHA-Stimulierung war nach links verschoben (niedrigere PHA-Dosis), die DNA-Synthese war bei den getesteten PHA-Dosierungen signifikant erhöht. Das Plasma von den Hepatitiskranken erwies sich weder als hemmend noch als stimulierend. Der Prozentsatz von E-Rosetten-bildenden Zellen war abgesunken, aber die Gesamtzellenzahl war normal. Die mittlere Prozentzahl von Ig-tragenden Zellen war normal, jedoch schwankten die einzelnen Werte in einem breiten Bereich. Es ist zu vermuten, wenigstens bei chronischen Erkrankungen, daß eine gesteigerte PHA-Reaktion auftritt, sowie eine prozentuale Zunahme von Zellen, die weder als B-noch als T-Zellen bei der Markierung in Erscheinung traten.
    Notes: Summary Lymphocytes from 22 children affected by chronic hepatitis were studied and a comparison was made with a control group of 32 healthy children in the same age range with respect to PHA dose-response curves, E-rosette formation and membrane immunoglobulin (Ig). From the results it appeared that PHA dose-response curves were displaced to the left (low PHA dose), DNA synthesis was significantly higher for all PHA dosages tested, and that the plasma of chronic hepatitis patients acted neither as inhibitor nor stimulator. The percentage of E-rosette-forming cells decreased, but the total number was normal. The mean percentage of Ig-bearing cells was normal but the single values were spaced over a wide range. It can be assumed that, at least in the chronic stage, there is an enhanced response to PHA and an increased percentage of cells without markers either for T or for B cells.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7284
    Keywords: Absence of CNS disease ; Toscana-virus infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In central Italy, acute lymphocytic meningitis and meningoencephalitis due to a Phlebotomus transmitted virus (Phlebovirus Toscana, TOSv) occurring throughout the summer are frequently observed. Several serum specimens of patients hospitalized with a clinical picture of viral meningitis/meningoencephalitis showed anti TOS-IgG reactivity suggestive of a previous infection occurring at an unknown time in the past. This observation led us to design a serological investigation of 83 household contacts of 46 summertime CNS infection patients (index cases) with the purpose of evaluating the percentage of both IgG and IgM in seropositive healthy individuals, living, like the index cases, in areas at high risk of phlebotomine sandfly bites. The serological study was carried out using an ELISA method: 22% of the sera showed a reactivity for anti-TOS IgG antibodies and 6% resulted IgG/IgM positive; none of them reported having had any symptoms of CNS involvement; the distribution of seropositive cases was similar in contacts of both TOS-confirmed and TOS-negative cases. Our results indicate: (1) that phlebovirus Toscana is frequently implicated in cases with CNS disease as well as in infections occurring without neurological involvement; (2) in our country the ecological requirements encompass the conditions in and around the human settlements for phlebotomine sandflies to become peridomestic thus amplifying the risk of TOSv infections, which are in fact widespread and frequent in Siena and its surroundings.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of epidemiology 6 (1990), S. 105-107 
    ISSN: 1573-7284
    Keywords: Hepatitis A ; Epidemiology ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over a period of seven years (from 1980 to 1987) 58 acute viral hepatitis A cases were admitted to the Departments for Infectious Diseases. This number represents 10.76% of all viral hepatitis patients. Most of the patients had travelled to foreign countries or to areas in Italy with high hepatitis A virus (HAV) circulation. An assessment of specific immunization against HAV in normal healthy people aged 1–60, performed by ELISA, showed a very low number of sero-positive subjects. The disappearance of HAV in Italy, which is similar to other western European countries, is probably due to the improved socio-economical conditions; the “imported cases” seem to have little impact on public health.
    Type of Medium: Electronic Resource
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