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Experimental corticosteroid myopathy (1981)

Braunstein, P. W. ; Girolami, U.

Springer

Acta neuropathologica 55 (1981), S. 167-172

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Details

ISSN: 1432-0533

Keywords: Myopathy ; Pathology ; Rat ; Steroid

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The steroids triamcinolone, dexamethasone, beta-methasone, and cortisone were administered i.p. to adult rats for 14–63 days. The extensor digitorum longus (EDL, white muscle) and soleus (SOL, red muscle) muscles were examined histologically and histochemically. Triamcinolone was the most potent lesion-producing drug. Selective involvement of muscles, and of the fiber types within them was observed: Neerotic changes were seen only in the type 1 fibers of the SOL; atrophic fibers were observed in the type 2 fibers of both the SOL and the EDL.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00691314

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