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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 17 (1993), S. 712-718 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La lobectomie “en manchonnage” est une méthode de résection indiquée en cas tumeur centrale pour laquelle la seule alternative aurait été une pneumonectomie. Cette intervention conserve du tissu pulmonaire normal et convient aux patients ayant une réserve cardiaque ou pulmonaire limite. Notre expérience s'étend de Janvier 1972 à Décembre 1991, période durant laquelle 142 patients ont eu une résection en “manchonnage” pour cancers bronchopulmonaires divers. La majorité des interventions étaient des résections du lobe supérieur (n = 110) et la plupart des interventions ont été classées comme curatives ou potentiellement curatives (87%). Il y a eu 3 morts postopératoires (mortalité chirurgicale de 2.5%) et une atélectasie prolongée a été la complication la plus fréquente (n = 9). Le suivi a été complet pour les 139 survivants (suivi moyen de 2149 jours); la survie globale a été de 46% à 5 ans et 33% à 10 ans. La survie à 5 et à 10 ans chez les patients ayant une maladie stade I a été respectivement de 63% et 42% alors que seulement 14% des patients stade III ont survecu 5 ans. Les récidives locales sont survenues chez 23% des patients mais lorsque la résection était complète, cette incidence a été de 17% (21/124). Ces résultats indiquent que la résection “en manchonnage” est une intervention suffisante pour la plupart des patients. La mortalité opératoire, la survie et l'incidence des récidives locales ne sont pas différentes de celles observées avec des procédés conventionnels.
    Abstract: Resumen La lobectomía con resección en manguito es un procedimiento que preserva tejido pulmonar y que usualmente está indicado para tumores de ubicación central para los cuales la alternativa es la neumonectomía. Al conservar parenquima pulmonar, puede lograrse la resección en pacientes seleccionados con reserva funcional cardiopulmonar inadecuada. Nuestra experiencia se extiende entre enero de 1972 hasta diciembre de 1991, periodo durante el cual 142 pacientes con tumores broncogénicos fueron sometidos a una variedad de resecciones en manguito. La mayoría fueron resecciones en manguito del bronquio del lóbulo superior (N = 110) y casi todos fueron considerados como completas y potencialemte curativas (87%). Se registraron tres muertes postoperatoria (mortalidad quirúrigica de 2.5%); la atelectasis prolongada constituyó la complicación más común (N = 9). El seguimiento fue completo para los 139 sobrevivientes (promedio de seguimiento de 2.149 días) y la tasa global de sobrevida fue de 46% a 5 años y de 33% a 10 años. La sobrevida a 5 y 10 años para los pacientes en estados I fue 63% y 52%, respectivamente, mientras sólo 14% de los pacientes con estado II sobrevivieron 5 años. Se observó recurencia local en 23% de los pacientes, pero cuando la resección fue completa, la tasa fue de 17% (21/124). Estos resultados indican que la resección en manguito es una operación oncológica adecuada tanto para los pacientes en buen estado general como para los que tienen compromiso funcional. La mortalidad operatoria, las tasas de sobrevida y de recurrencia local no son diferentes de las que se observan luego de procedimientos más convencionales.
    Notes: Abstract Sleeve lobectomy is a lung-saving procedure usually indicated for central tumors for which the alternative is a pneumonectomy. It preserves normal lung tissue and may enable pulmonary resection to be done in selected patients with inadequate cardiac or pulmonary reserve. One experience extends from January 1972 to December 1991, during which time 142 patients underwent a variety of sleeve resections for bronchogenic neoplasms. The majority of operations were upper-lobe sleeve resections (N=110) and most procedures were considered complete and potentially curative (87%). There were three postoperative deaths (surgical mortality of 2.5%) and prolonged atelectasis was the most common major complication (N=9). Follow-up was complete for the 139 survivors (mean follow-up time of 2,149 days) and overall survival was 46% at 5 years and 33% at 10 years. Five- and 10-year survivals for patients with stage I disease were 63% and 52%, respectively, while only 14% of patients with stage III disease survived 5 years. Local recurrences occurred in 23% of patients but when the resection had been complete, this incidence was 17% (21/124). These results indicate that sleeve resection is an adequate cancer operation for both compromised and uncompromised patients. Operative mortality, survival, and incidence of local recurrence are not different than what is seen after more conventional procedures.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7217
    Keywords: breast cancer ; cathepsin D ; immunohistochemistry ; protease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was aimed at investigating the influence of cathepsin D (CD) expression by cancer cells and stromal cells on breast cancer prognosis. This is a study of 1348 node‐positive (NPBC) and node‐negative (NNBC) breast cancers diagnosed between 1980 and 1986 and with a minimum follow‐up of 5.2 years. CD expression was assessed by immunohistochemistry on archival material using a polyclonal antibody. The expression by cancer and stromal cells was assessed separately and correlated with distant metastasis free (DMFS) and overall survival (OS). Cancer cells expressed CD (more than 10% cells expressing CD) in 38.9% of cases and reactive stromal cells in 43.6%. CD expression by reactive stromal cells, and not cancer cells, correlated with several factors of poor prognosis by cancer cells. A strong association was also found with expression of other proteases (stromelysin‐3, gelatinase A, and urokinase Plasminogen Activator) by these same reactive stromal cells. CD expression by cancer cells did not predict DMFS or OS but, by univariate analysis, CD expression by reactive stromal cells was associated with earlier recurrence and shorter survival in NNBC (p = 0.0425) and NPBC patients submitted to adjuvant chemotherapy (p = 0.0234). However, CD expression by reactive stromal cells remained a significant predictor of recurrence by multivariate analyses only in a subgroup of NPBC submitted to adjuvant chemotherapy. Overall, those data support the concept that proteases produced by reactive stromal cells are under cancer cell stimulation and that CD by stromal cells, and not cancer cells, influences the prognosis, but only in a subgroup of patients with breast cancer.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7217
    Keywords: breast cancer ; heat-shock ; prognostic factors ; stress-related protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunostaining for heat-shock protein-27 (HSP-27) was performed on formalin fixed-paraffin embedded sections of 890 node-positive breast carcinomas resected between 1980 and 1986. The follow-up ranged from 2.5 to 10.5 years. A polyclonal antibody (Hu27, dilution: 1/200) was used. A positive cytoplasmic staining was obtained in 383 cases (43%). No difference in distant metastasis-free survival (DMFS) or overall survival (OS) was noted between cases with positive or negative immunostaining. This study suggests that HSP-27 expression is not predictive of the outcome in node-positive breast cancer.
    Type of Medium: Electronic Resource
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