ISSN:
1600-051X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: Interleukin-2 (IL-2) is a pro-inflammatory cytokine derived from Th1 cells. This cytokine is involved in B-cell activation and stimulates macrophages, natural killer cells, T-cell proliferation and osteoclast activity. IL-2 has been also implicated in the stimulation of osteoclast activity in bone resorption.Objective: In this study the relationship between the polymorphism − 330 (T→G) in the IL-2 gene and different levels of chronic periodontal disease was investigated.Material and Methods: DNA was extracted from buccal epithelial cells of 113 unrelated adult individuals acting as controls and with different levels of periodontitis. The PCR-RFLP technique was used to investigate the polymorphism in the promoter of IL-2 gene.Results: When comparing the data of three groups of patients (Control, Moderate and Severe) we did not find significant differences between the studied IL-2 polymorphism and severity levels of PD. However, when the Control and Moderate phenotypes were grouped together and compared with genotypes TT vs. TG/GG, a significant difference was observed.Conclusion: We conclude that the − 330 (T→G) polymorphism in the IL-2 gene is associated with the severity of periodontal disease. The results presented in this study suggest an active role of IL-2 in the pathogenesis of periodontal disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-051X.2002.290701.x
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