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  • 1
    Electronic Resource
    Electronic Resource
    Reduction of HTLV-I-infected cells in blood by leukocyte filtration (1993)
    Springer
    Annals of hematology 67 (1993), S. 295-300 
    Details
    ISSN: 1432-0584
    Keywords: Blood transfusion ; Leukocyte filtration ; Human T-lymphotropic virus type I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Leukocyte filtration was performed with HTLV-I-infected blood and with blood supplemented with cultured HTLV-I-transformed cells. Reduction of infectivity upon leukocyte filtration was determined by the polymerase chain reaction (PCR) using primers indicative for the HTLV-I-pol andtax genes. Two different commercially available filters were used: a columnshaped cellulose acetate and a flat-bed polyester filter. Both filters yielded reduction of at least 310logs for cultured HTLV-I-infected cells. When blood from HTLV-I-infected individuals was used for filtration, the number of infected cells was reduced by 1–310logs. Although filtered blood as yet cannot be regarded as safe, it is concluded that leukocyte filtration of HTLV-I-infected blood potentially contributes to reducing the spread of HTLV-I by blood transfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696350
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    New distal marker closely linked to the fragile X locus (1991)
    Springer
    Human genetics 〈Berlin〉 87 (1991), S. 369-372 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and DXS304, both of which are closely linked distal markers for fragile X. This regional localization was supported by the analysis, in fragile X families, of recombination events between these three loci, the fragile X locus and locus DXS52, the latter being located at a more distal position. DXS466 is closely linked to the fragile X locus with a peak lod score of 7.79 at a recombination fraction of 0.02. Heterozygosity of DXS466 is approximately 50%. Its close proximity and relatively high informativity make DXS466 a valuable new diagnostic DNA marker for fragile X.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200922
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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