ISSN:
1432-0878
Keywords:
Intermediate filaments
;
Mitosis
;
Colonic epithelium
;
Man
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary An ultrastructural analysis of the organisation of 10 nm intermediate filaments during mitosis, in normal and malignant human colonic epithelial cells present in resected material, was carried out. Similar changes in the integrity of the 10 nm filaments were seen both in normal mitotic cells (which have a highly specialised filamentous network during interphase), and malignant cells (which show a disorganised network during interphase). The 10 nm filaments were seen to shorten and ‘fray’ in early mitosis. This was associated with the formation of spheroidal aggregates of thin filaments and small granules, both free in the cytoplasm and associated with surface desmosomes. At mid-mitosis cells were essentially devoid of obvious filamentous material, (including the spheroidal aggregates). The filaments reformed in daughter cells after cytokinesis was completed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00212229
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