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  • 1
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Event-related potentials were recorded from outpatient adult schizophrenics receiving maintenance doses of neuroleptics and from normal control subjects during performance of a reaction time task and a complex visual discrimination task, the Span of Apprehension. Difference potentials were computed to isolate endogenous activity associated with the processing demands of the Span task. Schizophrenics produce significantly less early endogenous negative activity than do normal subjects. This processing-related negativity reflects pattern matching activity to an attentional trace during the serial scan of the visual icon. We previously reported an identical reduction in processing-related negativity in childhood-onset schizophrenia, suggesting that this deficit is age independent. Both frontal contingent negative variation and an early frontal P3 were larger in the schizophrenics than in normal subjects, suggesting an inappropriate mobilization of nonspecific attentional resources. A later posterior P3 was significantly smaller in schizophrenics than in normal subjects.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 28 (1991), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: An elementary neural model of the P3 is proposed in which the P3 is held to manifest a brief, widely-distributed, inhibitory event. A preliminary and indirect test of the model is described using secondary-task methodology. Manual reaction times were measured to probe clicks delivered during the presumed time-course of an auditory oddball P3. We observed that reaction times to probes presented after oddball stimuli were significantly slowed as compared to reaction times to probes presented after standards. The latency of maximum reaction time slowing corresponded generally to the latency of the P3. The latency of maximum reaction time slowing did not respond to a manipulation varying the latency of the P3. Thus, some of the obtained results were consistent with the P3-inhibition hypothesis, whereas others were not. Secondary-task methodology may provide a valuable new approach to understanding the late event-related potentials.
    Type of Medium: Electronic Resource
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