ISSN:
1600-0536
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The low-molecular-weight phenols 2-methylol phenol (2-MP), 4-methylol phenol (4-MP), 2,4,6-trimethylol phenol (2,4,6-MP), 3-methylol phenol (3-MP), 2,4-dimethylol phenol (2,4-MP), and 2,6-dimethylol phenol (2,6-MP) are contact sensitizers in resins leased on phenol and formaldehyde (P-F-R). Other chemically related low-molecular-weight phenols are common in the environment. In patients hypersensitive to P-F-R and MPs, it is for diagnostic, therapeutic and preventive reasons necessary to know their cross-reaction patterns, which this study was therefore designed to investigate. In patients with contact allergy to a P-F-R and at least 1 MP, additional patch testing was performed with 6 MPs and 13 chemically related compounds. The 19 substances were tested at equimolar concentrations and in serial dilutions. Investigations by high-performance liquid chromatography were carried out to exclude contamination as the cause of the patch test reactions. Probable cross-reacting substances were o-cresol, p-cresol, salicylaldehyde, 2.4-dimethyl phenol, and 2.6-dimetrwl phenol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0536.1997.tb00044.x
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