ISSN:
1573-1111
Keywords:
cyclosporin A
;
X-ray structure analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A series of isomorphous clathrates(cyclosporin A: solvent = 1 : 1) is reported. Thestructure of the tetrahydrofuran (1) anddibutylether (2) clathrates have been determinedby X-ray single crystal diffraction. The cyclosporinmolecules in both structures are associated via vander Waals interactions forming cavities occupied bysolvent molecules. The structure refinement based onroom-temperature data sets show significant disorderof the side chains of the cyclosporin A molecule withno adequate model of the solvent molecule in bothstructures. In contrast, the position of dibutyletherwas successfully localised using a low-temperaturedata set for 2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008115029334
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