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HUMAN CHORIONIC SOMATOMAMMOTROPHIN (HCS): A NEW INDEX OF PLACENTAL FUNCTION (1971)

Teoh, Eng Soon ; Spellacy, William N. ; Buhi, William C.

Oxford, UK : Blackwell Publishing Ltd

BJOG 78 (1971), S. 0

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ISSN: 1471-0528

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: A simple, accurate and reproducible radio-immunosorbent technique has been developed to measure serum concentrations of chorionic somatomammotrophin (HCS). It appears to fulfil all the criteria for a good placental function test. The syncytiotrophoblast is the sole source of the hormone. It is easily measured in the serum from the 6th week until delivery. There is no circadian rhythm and the serum level is unaffected by stress or metabolic changes. It has a short half-life of 20 minutes. The serum HCS levels mirror the curve of fetal growth increment and low serum HCS concentrations were present in hypertensive disease of pregnancy. There appears to be a definite fetal danger zone separating normal from abnormal values. In cases of fetal death in hypertensive disease of pregnancy the serial serum HCS readings entered this zone before fetal demise. Serum HCS estimation was not helpful in diabetes nor in rhesus sensitization.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-0528.1971.tb01628.x

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Cloning of a novel rat placental prolactin-like protein C-related cDNAThe nucleotide sequence reported in this paper has been submitted to the GenBank/EMBL Data Bank, and may be located with the accession number U09099. (1995)

Conliffe, Phyllis R. ; Simmen, Rosalia C. M. ; Buhi, William C. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 41 (1995), S. 167-176

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ISSN: 1040-452X

Keywords: Prolactin ; Placenta ; Pregnancy ; Rodent ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: Prolactin-like protein C (PLP-C) is a major rat placental protein which is expressed during the second half of pregnancy and belongs to the growth hormone-prolactin family. Here we report on the isolation of overlapping rat placental cDNAs which specify a transcript of 915 base pairs and predict a 205-amino acid translated product. The full-length cDNA shares 93% homology with the nucleotide sequence reported for PLP-C, and the putative protein, which we designate PCRP (prolactin-like protein C-related protein), exhibits 88% homology with the PLP-C precursor protein. PCRP lacks the signal sequence and the first 2 N-terminal cysteine residues present in PLP-C. Northern blot analysis indicated the basal zone-specific expression of PCRP mRNA, with no detectable expression in decidua and labyrinth. Southern blot analysis of rat genomic DNA using PCRP cDNA as a probe demonstrated multiple hybridization bands, suggestive of a family of genes encoding prolactin-like proteins. Western immunoblot analysis of basal zone culture media using a PCRP antipeptide antiserum revealed at least 5 immunoreactive proteins. The existence of a PLP-C family of proteins in rat placenta after midpregnancy suggests their functional significance in the maintenance of pregnancy and fetal development. © 1995 Wiley-Liss, Inc.

Additional Material: 6 Ill.