ISSN:
1600-0536
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Introduction: Cutaneous adverse reactions from topical or systemic administration of non-steroidal anti-inflammatory drugs (NSAID) are frequently described. New cases of adverse reactions from NSAIDs are reported, but the most frequently involved are drugs as ketoprofen or piroxicam. We report a case of photoallergical contact dermatitis from diclophenac with possible cross reaction to aceclophenac.Material and methods: A 63-year-old-man, allergic to penicillin, developed eczematous lesions on hands and face, after applying a medicament containing diclophenac. Patch test and photopatch test (5 J/cm2) were performed with a photoallergen battery (Chemotechnique diagnosticsÒ), a NSAIDs battery (Aristegui lab.Ò) and aceclophenac 1%, 5% and 10% in pet. Readings were done at 48 and 96 hours in epicutaneous test and at 24 and 72 hours in photoallergic study, following the ICDRG criteria.Results: The results of photoallergic study were as follows: diclophenac 1%, 5% and 10% in pet. and aceclophenac 10% in pet. positive at 24 and 72 hours. The remaining compounds of the NSAIDs battery were negative.Conclusions: Diclophenac is a NAIDs derived from aryl alcanoic acid group used both topically and systemically in Spain. Some adverse reactions have been reported as exanthema, urticaria, eczema or Steven-Johnson’s syndrome. We have found only two cases reported as photosensitization from diclophenac. In one of them, the clinical lesion was described as a granuloma annular-like and photoallergic study was negative. We report a photocontact dermatitis from diclophenac with positive photopatch test. Photopatch test positive to aceclophenac may be explained as a cross reaction among group.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.0105-1873.2004.0309gz.x
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