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  • 1
    Electronic Resource
    Electronic Resource
    Intracranial germ cell tumour (embryonal carcinoma with teratoma) with complex karyotype including isochromosome 12p (1998)
    Springer
    Virchows Archiv 433 (1998), S. 571-574 
    Details
    ISSN: 1432-2307
    Keywords: Key words Isochromosome 12p ; Brain tumour ; Germ cell tumour ; Teratoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report the chromosomal characteristics of a malignant teratoma with embryonal carcinoma component located in the pineal region of a 15-year-old boy. Chromosome analysis showed a near-triploid complex karyotype (62 chromosomes), including two copies of an isochromosome 12p, confirmed by fluorescence in situ hybridization analysis. The present findings indicate that isochromosome 12p formation is probably associated with the development of malignant germ cell tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050291
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mammary foam cells (1998)
    Springer
    Virchows Archiv 432 (1998), S. 433-440 
    Details
    ISSN: 1432-2307
    Keywords: Key words Breast ; Foam cells ; Immunohistochemistry ; GCDFP15-PIP gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cells showing abundant, finely vacuolized cytoplasm (foam cells) are found frequently in most benign lesions of the breast and in certain malignant breast tumours. The origin of mammary foam cells (FCs) has not been clarified, and we therefore studied the morphological features of mammary FCs in a series of 50 benign lesions. The FCs were subdivided, on the basis of their distribution into FCs lining the glandular lumina, intraluminal FCs, intraepithelial-pagetoid FCs, and stromal FCs. The lesions were tested with a panel of antibodies against macrophage (MAC 387, CD68) and epithelial (epithelial membrane antigen [EMA], gross cystic disease fluid protein 15 [GCDFP15] and cytokeratin) markers. The lesions were examined for the presence of PIP/GCDFP15-specific mRNA by an in situ hybridization technique. Three different types of FCs were identified. Type A FCs are epithelial cells (positivity with EMA and cytokeratin) and show apocrine differentiation (positivity with GCDFP15 antiserum and expression of PIP/GCDFP15 mRNA). Type B FCs are of macrophage origin, as they are positive with the macrophage markers and lack cytokeratin and PIP/GCDFP15 mRNA. Finally, type C FCs show an intermediate profile between an epithelial cell and a macrophage: they are both CD68 and GCDFP15 positive and show a thin peripheral rim of positivity with anti-cytokeratin antibody. They lack PIP/GCDFP15 mRNA. Our results indicate the possibility of a spectrum of phenotypes in mammary FCs, from epithelial-apocrine cells to macrophage-derived phagocytic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050187
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Toxicity and cytotoxicity of nigrin b, a two-chain ribosome-inactivating protein from Sambucus nigra : comparison with ricin (1997)
    Springer
    Archives of toxicology 71 (1997), S. 360-364 
    Details
    ISSN: 1432-0738
    Keywords: Key words Nigrin b  ;  Ribosome-inactivating proteins  ;  Lectins  ;  HeLa cells  ;  Toxicity to mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nigrin b, a lectin isolated from the bark of elderberry (Sambucus nigra L.), has structure and enzymatic activity similar to that of ricin and other type 2 ribosome-inactivating proteins (RIPs), and yet is much less toxic to cells and animals. In an attempt to explain this difference, we studied (1) the cytotoxicity of both lectins at 18 and 37 °C, and in the presence of substances interfering with intracellular routing, and (2) the binding of nigrin b to, and its uptake and degradation by HeLa cells, in parallel with ricin. As compared with the latter, (1) less nigrin b was bound and more was degraded by cells, with a resulting lower concentration remaining inside the cells, and (2) there is evidence for a different intracellular routing followed by the two lectins. These results may explain at least partly the different cytotoxicity and consequently the lower toxicity to mice of nigrin b compared with ricin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050399
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    Paper (German National Licenses)
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