ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Monoclonal antibodies made against lymphocyte differentiation antigens were used to characterize phenotypically the lymphoid cell subpopulations in sections of human lymphoid tissue and inflamed gingival tissue associated with the deciduous dentition in children. Four monoclonal antibodies designated FMC 1, FMC 4, FMC 7, and UCHT1 were used. These antibodies are specific for B-cells, p28,33 (la-like) antigen, a B-cell subset, and peripheral T-cells respectively. FMC 1 and FMC 4 positive cells (B-cells) were found mainly in the secondary follicles while UCHT1 positive cells (T-cells) were found in the parafollicular areas of human tonsils. Cells in some, but not all, secondary follicles in the tonsils were FMC 7 positive.In the gingival tissue only 12.6 % of the infiltrating cells were FMC 1 positive, 12.2 % were FMC 4 positive, and 4.8 % FMC 7 positive. On the other hand over 75 % of cells appeared to be UCHT1 positive.These results indicate that the majority of inflammatory cells in gingivitis associated with the deciduous dentition in children have the phenotype B-cell antigen-/p28,33 (lalike) antigen-/B-cell subset antigen- and possibly T-cell antigen+. Such a phenotype is, at least by exclusion, suggestive of T-cells and as such confirms earlier studies using T-cell enzyme markers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1982.tb01151.x
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