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  • 1
    Electronic Resource
    Electronic Resource
    Experiences of stigmatization play a role in mediating the impact of disease severity on quality of life in psoriasis patients (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Psoriasis may have a severe impact on patients' quality of life (QOL) in several ways, an impact mediated by the mental or physical difficulties they have to deal with during the course of the disease and the various treatment regimens. In addition, psoriatic patients often suffer from experiences of stigmatization (EOS) related to the disease. Objectives This study was designed to test the hypotheses that psoriasis patients report higher levels of stigmatization than a comparison group, and that their EOS play a role in mediating the impact of the severity of psoriasis on their QOL. Methods One hundred patients with psoriasis (study group) and 100 patients with mixed skin problems (comparison group) were matched according to age, sex and education. All subjects answered questionnaires on EOS and QOL. A dermatologist diagnosed the diseases and measured severity scores. The Psoriasis Area and Severity Index score was used for psoriasis and a linear severity score for the comparison patients. The mediating effect of EOS was analysed using structural equation modelling (SEM). SEM is a multivariate statistical method used to examine the consistency of a theory relating one group of variables (termed a ‘latent construct’) to another: in the present study, the relationship between EOS and QOL. Results Psoriatic patients were found to report significantly higher levels of EOS related to the disease, compared with the comparison group. No significant differences were found regarding QOL or severity of disease. Clinical severity of psoriasis was found to correlate negatively with QOL in psoriasis patients. EOS were found to have a complete mediating effect for the severity of disease on the QOL in patients with psoriasis. This result was not found among the comparison group patients. Conclusions The results of this study indicate that psoriasis patients experience higher levels of stigmatization than do other dermatological patients, and that these EOS mediate the association between disease severity and patients' reported low levels of QOL. Treatment of psoriatic patients should consider these results and should include tools for psychosocial intervention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04899.x
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  • 2
    Electronic Resource
    Electronic Resource
    Sulphasalazine in the treatment of pauciarticular-onset juvenile chronic arthritis (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 511-514 
    Details
    ISSN: 1434-9949
    Keywords: Sulphasalazine ; Pauciarticular-onset Juvenile Chronic Arthritis ; Nonsteroidal Anti-inflammatory Drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sulphasalazine in a dose of 50 mg/kg/day was administered to ten patients with pauciarticular-onset juvenile chronic arthritis (JCA), with active disease not adequately controlled by nonsteroidal anti-inflammatory drugs (NSAID). The treatment was initiated with 1/4 of this dose and increased by weekly increments of 250–500 mg until the total dose was reached. In all patients sulphasalazine was the first disease-modifying agent tried. Among nine of the ten patients there was significant improvement in all clinical scores, including the number of active joints and the severity grading (tenderness and limitation of motion). Within 3 months of sulphasalazine therapy the laboratory measurements revealed marked improvement in the erythrocyte sedimentation rate (ESR) and haemoglobin values. One patient, in whom the ESR and haemoglobin were normal at onset, had no change in clinical scores. Transient skin rash and elevated liver enzyme levels developed in one patient. These preliminary data suggest that sulphasalazine is an effective and safe second-line agent in the management of pauciarticular-onset JCA. More trials with this drug are needed, including double blind, to study efficacy and safety of sulphasalazine in JCA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231781
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  • 3
    Electronic Resource
    Electronic Resource
    Ilioinguinal nerve entrapment in a patient with systemic sclerosis (scleroderma) (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 540-541 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231789
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  • 4
    Electronic Resource
    Electronic Resource
    Beneficial effect of phlebotomy on hepatitis C virus-associated musculoskeletal manifestations (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 390-392 
    Details
    ISSN: 1434-9949
    Keywords: Arthritis ; Hepatitis C virus ; Iron overload ; Myalgia ; Phlebotomy ; Rheumatic manifestations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic hepatitis C virus (HCV) infection may lead to many extrahepatic manifestations which pose a serious therapeutic challenge. Recently, increasing evidence suggesting an association between iron overload and chronic HCV infection has emerged. However, the effect of iron reduction therapy on extrahepatic manifestations of HCV infection is unknown. We describe two patients with chronic HCV infection and severe rheumatic manifestations, namely: myalgia and seronegative nonerosive symmetrical polyarthritis. Interestingly, the response to anti-inflammatory and second line drugs was poor but unexpectedly recurrent phlebotomies was followed by marked improvement of the symptoms. This observation suggests that iron overload may have some role in the pathophysiology of HCV associated rheumatic complications. Further studies are needed to confirm our observation and to clarify the underlying mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01450898
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  • 5
    Electronic Resource
    Electronic Resource
    CLINHAQ Scale – Validation of a Hebrew Version in Patients with Fibromyalgia (2000)
    Springer
    Clinical rheumatology 19 (2000), S. 265-269 
    Details
    ISSN: 1434-9949
    Keywords: Key words:CLINHAQ – Fibromyalgia – Health status – Physical functioning – Validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Assessment of health status in patients with rheumatic disease, including fibromyalgia (FM), using structured questionnaires has become an important approach to evaluate treatment and outcome. The objectives of this study were to validate a translated version of the Clinical Health Assessment Questionnaire (CLINHAQ) to be used by Hebrew-speaking populations, and specifically to evaluate its usefulness in fibromyalgia syndrome (FM). The CLINHAQ was translated into Hebrew and administered to 90 women with FM along with the Hebrew versions of the Fibromyalgia Impact Questionnaire (FIQ) and the Quality of Life (QOL) Scale. The CLINHAQ includes scales of functional disability, helplessness, anxiety and depression, as well as assessment of current health status and satisfaction with this. All subjects were asked about the presence and severity (assessed by visual analogue scale) of current FM symptoms (pain, fatigue, anxiety etc.); a count of 18 tender points was conducted by thumb palpation, and tenderness thresholds were measured by dolorimetry. Test–retest reliability was assessed by Pearson correlation coefficients, and internal consistency was evaluated with Cronbach’s α coefficient of reliability. Construct validity was tested by correlating the CLINHAQ items with measures of symptom severity, count of tender point, tenderness thresholds, physical functioning measured by FIQ, and with a score of QOL. Test–retest reliability coefficients ranged from 0.82 to 0.99, and Cronbach’s α coefficients from 0.725 to 0.929. Significant moderate to high correlations were obtained between most subscales of CLINHAQ and measures of physical functioning, quality of life and severity of FM symptoms. In conclusion, the CLINHAQ is a reliable and valid instrument for measuring health status and physical functioning in Israeli women with FM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670070043
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  • 6
    Electronic Resource
    Electronic Resource
    Arthritis in Israeli spotted fever (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 580-581 
    Details
    ISSN: 1434-9949
    Keywords: Arthritis ; Rickettsia ; Mediterranean Spotted Fever ; Israeli ; Spotted Fever
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Of 15 patients hospitalized because of Israeli spotted fever, 3 developed arthritis during the course of the disease. Treatment with tetracycline was accompanied by full remission of the spotted fever including the arthritis. This suggests that arthritis is not a rare complication of Israeli spotted fever.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208161
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  • 7
    Electronic Resource
    Electronic Resource
    Cyclophosphamide therapy in a patient with membranoproliferative glomerulonephritis and essential mixed cryoglobulinaemia (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 395-396 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01450900
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  • 8
    Electronic Resource
    Electronic Resource
    Palindromic rheumatism in Israel — a disease entity ? A survey of 34 patients (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 507-511 
    Details
    ISSN: 1434-9949
    Keywords: Palindromic Rheumatism ; Episodic Arthritis ; Rheumatoid Arthritis ; Negev ; Israel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Over a period of 10 years 34 patients were diagnosed as suffering from palindromic rheumatism. Eightyone percent of the patients were of North African origin. This is significantly higher (p=0.01) than the ageadjusted origin of the general population in the region. Attacks were usually monoarthritic or oligoarthritic in nature. The joint most often involved was the knee. Prophylactic therapy with colchicine was ineffective. Gold salts brought about partial remission in three of six patients. Despite a relatively long average follow-up period of 9.3 years and the finding of a positive rheumatoid factor in 12% of the patients, not one of the patients developed rheumatoid arthritis. In 50% of the patients we detected an unexplained elevation in serum globulins and immunoglobulins. The possible association between this syndrome and Familial Mediterranean Fever is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032105
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  • 9
    Electronic Resource
    Electronic Resource
    Systemic Sclerosis: Another Rheumatic Disease Associated with Hepatitis C Virus Infection (2000)
    Springer
    Clinical rheumatology 19 (2000), S. 378-380 
    Details
    ISSN: 1434-9949
    Keywords: Key words: HCV – Interferon – Systemic sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The first case of a patient with chronic infection with hepatitis C virus who developed systemic sclerosis, manifested by severe Raynaud’s phenomenon, progressive skin thickening, painful fingertip ulcers, dysphagia and Sjogren’s syndrome, is described. The role of interferon therapy is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670070031
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  • 10
    Electronic Resource
    Electronic Resource
    Mud pack therapy in rheumatoid arthritis (1992)
    Springer
    Clinical rheumatology 11 (1992), S. 243-247 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Mud ; Balneotherapy ; Dead Sea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-eight patients with classical or definite rheumatoid arthritis were randomly divided into two groups of fourteen patients each. All patients were treated once a day with mud packs derived from the Dead Sea heated to 40°C and applied over the four extremities, neck and back for 20 minutes. Group 1 was treated with the true mud packs and Group 2 with washed out and less concentrated mud packs. The study was double blind and of two weeks duration. All patients were evaluated by one rheumatologist both before treatment and two weeks later at the end of the treatment period. Follow-up evaluations were made one and three months after conclusion of the treatment. The clinical indices evaluated included duration of morning stiffness, hand-grip strength, activities of daily living, patient's own assessment of disease activity, number of active joints and the Ritchie index. A statistically significant improvement (p〈0.01 or p〈0.05) was observed in Group 1 only in most of the clinical indices, lasting between 1 to 3 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207966
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