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  • 1
    Electronic Resource
    Electronic Resource
    Juvenile polyposis–a precancerous condition (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Clinical and pathological findings in 87 patients with juvenile polyposis have been reviewed; 1032 polyps were available from 80 of these patients; 840 were typical spherical juvenile polyps whereas 169 differed in being multilobulated or showing a villous configuration; 79 (46.7%) of the latter contained foci of epithelial dysplasia whereas only 76 (9.0%) of the typical juvenile polyps were dysplastic. The series also included 21 adenomas and two hyperplastic (metaplastic) polyps. The demonstration of dysplasia provides a histogenetic mechanism for the evolution of colorectal cancer from hamartomatous polyps; 18 juvenile polyposis patients have developed colorectal cancer at a mean age of 34 years (range 15–59). The clinical outcome was generally poor. No clinical or pathological distinction could be made between polyposis patients with and without colorectal cancer. Thus, the development of cancer in juvenile polyposis appears to be a random event. A working definition of juvenile polyposis is provided: (1) more than five juvenile polyps of the colorectum; and/or (2) juvenile polyps throughout the gastrointestinal tract; and/or (3) any number of juvenile polyps with a family history of juvenile polyposis. It is suggested that the condition should be treated as seriously as familial adenomatous polyposis except that regular colonoscopic surveillance may obviate the need for prophylactic colectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02093.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural features of the colonic epithelium in familial polyposis coli (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 1 (1977), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Colectomy specimens from 6 cases of familial polyposis coli (FPC) were examined. Macroscopically normal mucosa between polyps was taken at intervals along the ascending, transverse and descending colons and studied at EM level. All three regions show the same cell populations varying only in their ration and height of the epithelium. The same cell types seen in the normal crypt epithelium are present in teh mucosa from FPC. As in the normal, ‘intermediate’ cells are present in FPC but they are less conspicuous than in the mucosa adjacent to colonic carcinoma. However, there are ultrastructural features which distinguish the ‘normal’ mucosa in FPC from the true normal: (a): the presence of ‘clear columnar’ cells; (b) increased vesiculation in the absorptive cells; (c) large number of lysosomes; and (d)the presence of small electron-dense bodies. The ultrastructure of the ‘clear columnar’ cells suggests their being incompletely differentiated cells, thus raising the possibility that their presence in the upper crypt and surface epithelium may represent an early stage in the process of polyp and cancer formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1977.tb01649.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Invasion of veins by carcinoma of rectum: method of detection, histological features and significance (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 5 (1981), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histopathological material from operation specimens of rectal adenocarcinoma was reviewed and invasion of veins identified in 51.9% of 703 cases. The extent of venous invasion, thickness of the walls of invaded veins and various other histological features were examined in detail. By follow-up studies recurrence rates, incidence of distant metastases and corrected 5-year survival rates were obtained; correlation with the histopathological results showed that invasion of extramural and thick-walled veins is associated with a poor prognosis independent of the degree of differentiation of the adenocarcinoma. Prognosis is not significantly related to the presence of necrosis of intravenous growth. Aneurysmal distension and inflammatory damage of the walls of invaded veins, a thrombus cap or endothelial cell mantle covering intravenous tumour and a clearly defined stroma in the intravenous growth all appear to exert a protective influence on patient survival, whereas permeation of capillaries in vein walls, the presence of loose clumps of tumour cells in veins and direct contact between tumour cells and venous blood appear to adversely affect survival. Venous invasion is shown to be related to local invasiveness of rectal carcinoma. Suggested modes of venous spread and interaction with host tissues are proposed, with implications for general attitudes to the spread of cancer and metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1981.tb01774.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Localization of the gene for familial adenomatous polyposis on chromosome 5 (1987)
    [s.l.] : Nature Publishing Group
    Nature 328 (1987), S. 614-616 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Most of the families for the study were identified by the Polyposis Register at St Mark's Hospital, London and by the Gastroenterology Unit, Broadgreen Hospital, Liverpool, and were well characterized with respect to clinical, pathological and pedigree information. Sterile blood samples were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/328614a0
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    Paper (German National Licenses)
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