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Chagasic Patients Lack CD28 Expression on Many of Their Circulating T Lymphocytes (1996)

DUTRA, W. O. ; MARTINS-FILHO, O. A. ; CANÇADO, J. R. ; [et al.]

Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd

Scandinavian journal of immunology 43 (1996), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: A balanced host-parasite interaction during Trypanosoma cruzi infection allows for the establishment of a chronic infection that can last for many years. T cells are a major element responsible for parasite specific and non-specific immunityduring the complex immune response of the host. However, the sub-populations of T cells involved in the response, as well as the exact mechanisms through which those cells are activated or rendered unresponsive, are not well defined. It is known thatco-stimulatory signals, some of which are mediated via CD28, are of critical importance in the triggering of appropriate T cell responses. In this study the authors performed double-labelling studies to determine the frequency of expression of CD28 byCD4+ and CD8+ T lymphocytes in the peripheral blood of patients with Chagas’ disease. The results show that chagasic patients throughout the spectrum of chronic clinical forms of the infection have significantly higher meanfrequencies of CD4+CD28– and CD8+CD28– T cells, as compared with non-chagasic individuals. Considering the importance of CD28 for T-cell activation, the observed down-regulation or loss of CD28during infection may indicate a possible basis for observed immunoregulatory events or distinct stages of T-cell activation in this infection. Recent evidence from patients with HIV/AIDS indicates that CD28– cell populations are morelikely to undergo apoptosis, and increased apoptosis has been observed in experimental Chagas disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-9.x

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Acyl fluorides as reactive mimics of aldehyde pheromones: hyperactivation and aphrodisiac inHeliothis virescens (1986)

Prestwich, G. D. ; Carvalho, J. F. ; Ding, Y. -S. ; [et al.]

Springer

Cellular and molecular life sciences 42 (1986), S. 964-966

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ISSN: 1420-9071

Keywords: Acid fluoride ; aldehyde ; mating disruption ; pheromone analogs ; Heliothis ; Lepidoptera ; fluorination

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Substitution of fluorine for the aldehydic hydrogen provides behaviorally active, chemically reactive pheromone mimics. In male moths of the tobacco budwormHeliothis virescens, Z9–14:Acf and Z11–16:Acf cause hyperactivity and irreversible extension of the genitalia in over 80% of treated moths. In addition, a combination of the two components leads to 10–50% of the pairs involving one treated partner becoming locked in copula.