ISSN:
1573-7284
Keywords:
Gemfibrozil
;
HDL-cholesterol
;
LDL-cholesterol
;
Triglycerides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Gemfibrozil (G) is a widely used and highly effective fibric and acid derivative. It acts both on lipoprotein disorders characterized by hypertriglyceridemia, as well as in hyperchlolesterolemia. The results of two separate studies are summarized, in order to elucidate the differential activity profile of the drug on the major plasma lipoprotein parameters. In a group of hypertriglyceridemic patients (Study I) the major activity of G was on the VLDL cholesterol (C) and triglyceride levels (respectively - 40.4 and - 35.7%), associated with a marked increase of the HDL-C levels, in particular in the HDL3 subfraction. In addition, apolipoprotein B levels were significantly reduced (-12%) in all treated patients. In Study II, treatment with G in severe hypercholesterolemia was compared to that with pravastatin, a major hydroxymethylglutaryl coenzyme A reductase inhibitor. G, in these patients, markedly reduced both total (- 21.6%) and LDL-cholesterol (- 24.4%) levels. The increase of HDL-C was less marked than in type IV patients but G, similarly to pravastatin, induced a significant reduction of apolipoprotein B, together with an increase (+ 19.2%) of apolipoprotein All levels. These findings indicate that the activity profile of G is wider than expected and that it may include a reduction of LDL levels in severely hypercholesterolemic patients. The mechanism of this latter change is difficult to establish, although it may also be related to an improved delipidation of LDL, resulting in a more efficient interaction with peripheral high affinity receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00145362
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